Delayed brainstem auditory evoked responses in experimental diabetes mellitus

The brainstem auditory evoked responses (BAER) were utilized for the evaluation of central neural transmission in alloxan-induced diabetes in rats. The mean latencies of waves I, III, V and the interpeak latencies III-V and I-V were prolonged in diabetic rats as compared to the same rats before allo...

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Bibliographic Details
Published in:Journal of laryngology and otology 1986-08, Vol.100 (8), p.883-891
Main Authors: BULLER, N, LAURIAN, N, SHVILI, I, LAURIAN, L
Format: Article
Language:English
Subjects:
Animals
Audiometry, Evoked Response
Biological and medical sciences
Brain Stem - physiopathology
Central Nervous System Diseases - diagnosis
Diabetes Mellitus, Experimental - physiopathology
Diabetes. Impaired glucose tolerance
Diabetic Neuropathies - diagnosis
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Male
Medical sciences
Rats
Rats, Inbred Strains
Time Factors
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Summary:The brainstem auditory evoked responses (BAER) were utilized for the evaluation of central neural transmission in alloxan-induced diabetes in rats. The mean latencies of waves I, III, V and the interpeak latencies III-V and I-V were prolonged in diabetic rats as compared to the same rats before alloxan administration. The incidence of abnormal BAER was more frequent in the group of rats with severe diabetes (82 per cent) than in mildly diabetic animals (42 per cent). Our results may suggest the presence of a central neuropathy in experimental diabetes, which can be detected by the method of BAER.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215100100271