Microbial Transformation of Hypoestenone

Preparative-scale fermentation of hypoestenone (1) with Mucor raman nianus (ATCC 9628) has resulted in the isolation of 8(9)α-epoxyhypoestenone (2) and the new metabolites 8(9)α-epoxy-12,13-anhydrohypoestenone (3), 17-hydroxyhypoestenone (4), 13α,18-dihydroxyhypoestenone (5), and 13β,18-dihydroxyhyp...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2001-03, Vol.64 (3), p.373-375
Main Author: El Sayed, Khalid A
Format: Article
Language:English
Subjects:
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Biotransformation
Diterpenes - chemistry
Diterpenes - metabolism
Fundamental and applied biological sciences. Psychology
Magnetic Resonance Spectroscopy
Magnoliopsida
Methods. Procedures. Technologies
Mucor - metabolism
Plant Extracts - metabolism
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Summary:Preparative-scale fermentation of hypoestenone (1) with Mucor raman nianus (ATCC 9628) has resulted in the isolation of 8(9)α-epoxyhypoestenone (2) and the new metabolites 8(9)α-epoxy-12,13-anhydrohypoestenone (3), 17-hydroxyhypoestenone (4), 13α,18-dihydroxyhypoestenone (5), and 13β,18-dihydroxyhypoestenone (6). Structure elucidation of these metabolites was based primarily on 1D and 2D NMR analyses.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0005255