Budding Process and Fine Structure of Lymphadenopathy-associated Virus (LAV)

The budding process and fine structure of lymphadenopathy-associated virus (LAV), were studied by indirect immunofluorescence (IF) and electron microscopy (EM). By IF, LAV antigen was seen to be distributed focally within infected CCRF-CEM cells. Consistent with this finding, electron micrographs sh...

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Bibliographic Details
Published in:MICROBIOLOGY and IMMUNOLOGY 1986, Vol.30(6), pp.545-552
Main Authors: Tsuchie, Hideaki, Katsumoto, Tetsuo, Hattori, Naohiko, Kawatani, Toshio, Kurimura, Takashi, Hinuma, Yorio
Format: Article
Language:English
Subjects:
AIDS/HIV
Antigens, Viral - analysis
Biological and medical sciences
Cells, Cultured
Deltaretrovirus - growth & development
Deltaretrovirus - immunology
Deltaretrovirus - ultrastructure
Fundamental and applied biological sciences. Psychology
Microbiology
Microscopy, Electron
Microscopy, Electron, Scanning
Morphology, structure, chemical composition, physicochemical properties
Virology
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Summary:The budding process and fine structure of lymphadenopathy-associated virus (LAV), were studied by indirect immunofluorescence (IF) and electron microscopy (EM). By IF, LAV antigen was seen to be distributed focally within infected CCRF-CEM cells. Consistent with this finding, electron micrographs showed that LAV particles occurred in a focally aggregated state in a restricted area of the surface of the infected cells. LAV particles possessed bar-shaped, dense and central or eccentric cores. In addition, two or more cores were occasionally observed in one virus particle, or the cores were sometimes absent when thin sections were examined. The envelope of the virus particles had an irregular structure, although LAV particles were approximately spherical.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.1986.tb02980.x