NMDA glutamate receptor stimulation is required for the expression of D2 dopamine mediated responses in apomorphine primed 6-hydroxydopamine lesioned rats

Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-...

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Bibliographic Details
Published in:Brain research 2001-04, Vol.897 (1), p.213-216
Main Authors: Pollack, Alexia E., Haisley, Emily C.
Format: Article
Language:English
Subjects:
Animals
Apomorphine
Apomorphine - pharmacology
Behavior, Animal - drug effects
Biological and medical sciences
Brain Chemistry - drug effects
c-Fos
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
D2 Dopamine receptor
Denervation
Dizocilpine Maleate - pharmacology
Dopamine Agonists - pharmacology
Excitatory Amino Acid Antagonists - pharmacology
Fundamental and applied biological sciences. Psychology
Male
NMDA Glutamate receptor
Oxidopamine
Parkinson Disease - drug therapy
Parkinson Disease - metabolism
Piperazines - pharmacology
Priming
Proto-Oncogene Proteins c-fos - metabolism
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D2 - biosynthesis
Receptors, Dopamine D2 - metabolism
Receptors, N-Methyl-D-Aspartate - metabolism
Sympatholytics
Vertebrates: nervous system and sense organs
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Summary:Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenuates these quinpirole-mediated responses. These findings suggest that concomitant NMDA receptor stimulation is required for the expression of D2-mediated responses in apomorphine primed dopamine-depleted rats.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(01)02086-8