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NMDA glutamate receptor stimulation is required for the expression of D2 dopamine mediated responses in apomorphine primed 6-hydroxydopamine lesioned rats

Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-...

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Published in:	Brain research 2001-04, Vol.897 (1), p.213-216
Main Authors:	Pollack, Alexia E., Haisley, Emily C.
Format:	Article
Language:	English
Subjects:	Animals Apomorphine Apomorphine - pharmacology Behavior, Animal - drug effects Biological and medical sciences Brain Chemistry - drug effects c-Fos Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors D2 Dopamine receptor Denervation Dizocilpine Maleate - pharmacology Dopamine Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Male NMDA Glutamate receptor Oxidopamine Parkinson Disease - drug therapy Parkinson Disease - metabolism Piperazines - pharmacology Priming Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Sprague-Dawley Receptors, Dopamine D2 - biosynthesis Receptors, Dopamine D2 - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Sympatholytics Vertebrates: nervous system and sense organs
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container_title	Brain research
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description	Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenuates these quinpirole-mediated responses. These findings suggest that concomitant NMDA receptor stimulation is required for the expression of D2-mediated responses in apomorphine primed dopamine-depleted rats.
doi_str_mv	10.1016/S0006-8993(01)02086-8
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Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenuates these quinpirole-mediated responses. These findings suggest that concomitant NMDA receptor stimulation is required for the expression of D2-mediated responses in apomorphine primed dopamine-depleted rats.</description><subject>Animals</subject><subject>Apomorphine</subject><subject>Apomorphine - pharmacology</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry - drug effects</subject><subject>c-Fos</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>D2 Dopamine receptor</subject><subject>Denervation</subject><subject>Dizocilpine Maleate - pharmacology</subject><subject>Dopamine Agonists - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>NMDA Glutamate receptor</subject><subject>Oxidopamine</subject><subject>Parkinson Disease - drug therapy</subject><subject>Parkinson Disease - metabolism</subject><subject>Piperazines - pharmacology</subject><subject>Priming</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Dopamine D2 - biosynthesis</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Receptors, N-Methyl-D-Aspartate - metabolism</subject><subject>Sympatholytics</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkc9u1DAQhy0EokvhEUC-gMohxXZiJz6hquWfVOAAnC3HmbBGSZx6nKr7Kn1anO6qPfZk2fP9xvZ8hLzm7JQzrj78YoypotG6PGH8PROsybsnZMObWhRKVOwp2dwjR-QF4r-8LUvNnpMjzkUjyoZtyO2P7xdn9O-wJDvaBDSCgzmFSDH5cRls8mGiHvP51eIjdLTPtbQFCjdzBMS1HHp6IWgXZjv6CegInc-tupzBOUwISP1E7RzGEOftSszRZ4iqYrvrYrjZ3UcHWBuuUZvwJXnW2wHh1WE9Jn8-f_p9_rW4_Pnl2_nZZeEqIVKh2rbUump4Lx1Aa5nuWlELLkStrGwc75kua9fzqlXS2bJTLdeu0n0FUulalMfk3b7vHMPVApjM6NHBMNgJwoKmrhmvtZaPgrxuJK9UmUG5B10MiBF6s_7Yxp3hzKz2zJ09s6oxjJs7e6bJuTeHC5Y2D-ghddCVgbcHwKKzQx_t5Dw-cBWTWkqVuY97DvLcrj1Eg87D5LKZLDiZLvhHnvIfDsa5jQ</recordid><startdate>20010406</startdate><enddate>20010406</enddate><creator>Pollack, Alexia E.</creator><creator>Haisley, Emily C.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20010406</creationdate><title>NMDA glutamate receptor stimulation is required for the expression of D2 dopamine mediated responses in apomorphine primed 6-hydroxydopamine lesioned rats</title><author>Pollack, Alexia E. ; Haisley, Emily C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-6bb399481f5ceeba09db27212276a58c1f0937cf14b65ca3d6b19c49f4e569723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Apomorphine</topic><topic>Apomorphine - pharmacology</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry - drug effects</topic><topic>c-Fos</topic><topic>Central nervous system</topic><topic>Central neurotransmission. 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subjects	Animals Apomorphine Apomorphine - pharmacology Behavior, Animal - drug effects Biological and medical sciences Brain Chemistry - drug effects c-Fos Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors D2 Dopamine receptor Denervation Dizocilpine Maleate - pharmacology Dopamine Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Male NMDA Glutamate receptor Oxidopamine Parkinson Disease - drug therapy Parkinson Disease - metabolism Piperazines - pharmacology Priming Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Sprague-Dawley Receptors, Dopamine D2 - biosynthesis Receptors, Dopamine D2 - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Sympatholytics Vertebrates: nervous system and sense organs
title	NMDA glutamate receptor stimulation is required for the expression of D2 dopamine mediated responses in apomorphine primed 6-hydroxydopamine lesioned rats
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