Abnormalities of hemorheological, endothelial, and platelet function in patients with chronic Heart failure in sinus rhythm: Effects of angiotensin-converting enzyme inhibitor and β-blocker therapy

• Published in: Circulation (New York, N.Y.) N.Y.), 2001-04, Vol.103 (13), p.1746-1751
• Main Authors: GIBBS, Christopher R, BLANN, Andrew D, WATSON, Robert D. S, LIP, Gregory Y. H
• Format: Article
• Language: English
• Subjects: Adrenergic beta-Antagonists - therapeutic use; Aged; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Arrhythmia, Sinus; Biological and medical sciences; Blood Platelets - drug effects; Blood Platelets - metabolism; Blood Platelets - pathology; Cardiology. Vascular system; Chronic Disease; Cohort Studies; Cross-Sectional Studies; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; Female; Fibrinogen - metabolism; Heart; Heart Diseases - blood; Heart Diseases - drug therapy; Heart Diseases - pathology; Heart Diseases - physiopathology; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Hematocrit; Humans; Lisinopril - therapeutic use; Male; Medical sciences; Middle Aged; P-Selectin - metabolism; Platelet Count; Regression Analysis; Rheology; Sex Characteristics; Solubility; Statistics, Nonparametric; Viscosity; von Willebrand Factor - metabolism
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/01.CIR.103.13.1746

To investigate the hypothesis that abnormalities of hemorheological (fibrinogen, plasma viscosity), endothelial (von Willebrand factor [vWF]), and platelet (soluble P-selectin) function would exist in patients with chronic heart failure (CHF) who are in sinus rhythm, we conducted a cross-sectional study of 120 patients with stable CHF (median ejection fraction 30%). We also hypothesized that ACE inhibitors and beta-blockers would beneficially affect the measured indices. In the cross-sectional analysis, plasma viscosity (P=0.001), fibrinogen (P=0.02), vWF (P