Hypoxic constriction of porcine distal pulmonary arteries: endothelium and endothelin dependence

Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 To determine the role of endothelium in hypoxic pulmonary vasoconstriction (HPV), we measured vasomotor responses to hypoxia in isolated seventh-generation porcine pulmonary a...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2001-05, Vol.280 (5), p.856-L865
Main Authors: Liu, Q, Sham, J. S. K, Shimoda, L. A, Sylvester, J. T
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Bronchial Arteries - drug effects
Bronchial Arteries - metabolism
Bronchial Arteries - physiopathology
Caffeine - pharmacology
Calcium - metabolism
Calcium - pharmacology
Cell Survival
Endothelin-1 - metabolism
Endothelin-1 - pharmacology
Endothelium, Vascular - cytology
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
Enzyme Inhibitors - pharmacology
Hypoxia - metabolism
Hypoxia - physiopathology
In Vitro Techniques
Lung - blood supply
Lung - metabolism
Lung - physiopathology
Male
Pulmonary Artery - drug effects
Pulmonary Artery - metabolism
Pulmonary Artery - physiopathology
Receptors, Endothelin - metabolism
Ryanodine - pharmacology
Swine
Vasoconstriction - drug effects
Vasoconstrictor Agents - pharmacology
Vasodilator Agents - pharmacology
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Summary:Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 To determine the role of endothelium in hypoxic pulmonary vasoconstriction (HPV), we measured vasomotor responses to hypoxia in isolated seventh-generation porcine pulmonary arteries 
ISSN:1040-0605
1522-1504
DOI:10.1152/ajplung.2001.280.5.L856