Effect of non-insulin-dependent diabetes mellitus on myocardial insulin responsiveness in patients with ischemic heart disease

Patients with non-insulin-dependent diabetes mellitus (NIDDM) exhibit poor clinical outcomes from myocardial ischemia. This may reflect an impairment in their cardiac insulin-response system. We used AV balance and intracoronary infusion techniques to compare the intrinsic cardiac responsiveness to...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2001-04, Vol.103 (13), p.1734-1739
Main Authors: JAGASIA, Dinesh, WHITING, Jennifer M, CONCATO, John, PFAU, Steven, MCNULTY, Patrick H
Format: Article
Language:English
Subjects:
Angiography
Biological and medical sciences
Blood Glucose - drug effects
Cardiology. Vascular system
Coronary Circulation - drug effects
Coronary heart disease
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Fasting
Heart
Hemodynamics - drug effects
Humans
Insulin - pharmacology
Lactic Acid - blood
Male
Medical sciences
Middle Aged
Myocardial Ischemia - blood
Myocardial Ischemia - complications
Myocardial Ischemia - metabolism
Oxygen Consumption - drug effects
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Summary:Patients with non-insulin-dependent diabetes mellitus (NIDDM) exhibit poor clinical outcomes from myocardial ischemia. This may reflect an impairment in their cardiac insulin-response system. We used AV balance and intracoronary infusion techniques to compare the intrinsic cardiac responsiveness to insulin in 26 coronary disease patients with (n=13) and without (n=13) NIDDM. During fasting, NIDDM hearts demonstrated lower fractional extraction of glucose from arterial plasma than controls (1.0+/-0.5% versus 2.1+/-0.5%, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.103.13.1734