Divergent and convergent evolution of NK-cell receptors

Natural killer (NK)-cell receptors specific for major histocompatibility complex (MHC) class I molecules have been identified in humans and mice. Some of the most important receptors are structurally unrelated in the two species: the murine Ly-49 receptors are C-type lectins, while human killer-cell...

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Bibliographic Details
Published in:Trends in Immunology 2001, Vol.22 (1), p.52-57
Main Authors: Barten, Roland, Torkar, Michaela, Haude, Anja, Trowsdale, John, Wilson, Michael J
Format: Article
Language:English
Subjects:
Animals
Evolution
Evolution, Molecular
Humans
ILT
Immunoglobulin like transcript
Killer cell immunoglobulin-like receptor
killer cell inhibitory receptors
Killer Cells, Natural - chemistry
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
KIR
Leukocyte receptor cluster
LRC
Natural killer complex
NKC
Receptors, Immunologic - chemistry
Receptors, Immunologic - genetics
Receptors, Immunologic - physiology
Receptors, KIR
T-Lymphocyte Subsets - chemistry
T-Lymphocyte Subsets - immunology
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Summary:Natural killer (NK)-cell receptors specific for major histocompatibility complex (MHC) class I molecules have been identified in humans and mice. Some of the most important receptors are structurally unrelated in the two species: the murine Ly-49 receptors are C-type lectins, while human killer-cell inhibitory receptors (KIRs) belong to the immunoglobulin superfamily. Here, Roland Barten and colleagues describe the divergent and convergent evolution of NK-cell receptors.
ISSN:1471-4906
1471-4981
DOI:10.1016/S1471-4906(00)01802-0