Preliminary report: Effect of adrenal androgen and estrogen on bone maturation and bone mineral density

To clarify the independent physiological roles of adrenal androgen and estrogen on bone growth, we compared the lumbar spine bone mineral density (BMD) in prepubertal girls with virilizing congenital adrenal hyperplasia (CAH) (n = 17) and girls with central precocious puberty (CPP) (n = 18). When BM...

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Published in:Metabolism, clinical and experimental clinical and experimental, 2001-04, Vol.50 (4), p.377-379
Main Authors: Arisaka, Osamu, Hoshi, Megumi, Kanazawa, Sanae, Numata, Michio, Nakajima, Daisuke, Kanno, Shinko, Negishi, Masaho, Nishikura, Kiyoshi, Nitta, Akihisa, Imataka, Mariko, Kuribayashi, Takeshi, Kano, Kenichi
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adrenal Glands - physiology
Adrenal Hyperplasia, Congenital - metabolism
Adrenal Hyperplasia, Congenital - physiopathology
Age Determination by Skeleton
Androgens - physiology
Bone Density - physiology
Bone Development - physiology
Child
Estrogens - physiology
Female
Humans
Puberty, Precocious - metabolism
Puberty, Precocious - physiopathology
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Summary:To clarify the independent physiological roles of adrenal androgen and estrogen on bone growth, we compared the lumbar spine bone mineral density (BMD) in prepubertal girls with virilizing congenital adrenal hyperplasia (CAH) (n = 17) and girls with central precocious puberty (CPP) (n = 18). When BMD was analyzed according to chronologic age, no significant differences were found between CPP and CAH patients. However, when adjusted to bone age, BMD was statistically higher in CAH than in CPP subjects. This finding suggests that adrenal androgen, as well as estrogen, plays an important role in increasing BMD. Adrenal androgen may act on bone not only as androgen, but as estrogen after having been metabolized into an aromatized bone-active compound in peripheral tissues, such as bone and fat. Therefore, adrenal androgen may have a more important role in increasing BMD than previously realized.
ISSN:0026-0495
1532-8600
DOI:10.1053/meta.2001.21678