A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo

Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and th...

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Bibliographic Details
Published in:Trends in immunology 2001-03, Vol.22 (3), p.130-136
Main Authors: Das, Pranab K., van den Wijngaard, René M.J.G.J., Wankowicz-Kalinska, Anna, Le Poole, I.Caroline
Format: Article
Language:English
Subjects:
autoimmunity
Autoimmunity - immunology
Humans
infection
inflammation
Leprosy - immunology
melanocytes
Melanocytes - immunology
Melanoma - immunology
melanosomes
melonoma humour imunity
Skin - cytology
Skin - immunology
Skin - pathology
stress
Symbiosis
vitiligo
Vitiligo - immunology
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Summary:Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma.
ISSN:1471-4906
1471-4981
DOI:10.1016/S1471-4906(00)01844-5