Dendritic cells resurrect antigens from dead cells

Antigens that do not normally access the cytoplasm of antigen-presenting cells, such as certain tumor and viral antigens, become targets of cytotoxic T lymphocytes (CTLs). Over the past 25 years, substantial evidence has emerged for an ‘exogenous’ pathway for loading MHC class I molecules. Dendritic...

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Bibliographic Details
Published in:Trends in immunology 2001-03, Vol.22 (3), p.141-148
Main Authors: Larsson, Marie, Fonteneau, Jean Francois, Bhardwaj, Nina
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation - immunology
antigen presenting cells
Antigens - immunology
Autoimmunity - immunology
Cell Death
Cross Reactions
CTLs
dendritic cells
Dendritic Cells - immunology
Histocompatibility Antigens Class I - immunology
Humans
Immune Tolerance - immunology
MHC class-T
Models, Immunological
Neoplasms - immunology
T cells
T-Lymphocytes - immunology
Viruses - immunology
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Summary:Antigens that do not normally access the cytoplasm of antigen-presenting cells, such as certain tumor and viral antigens, become targets of cytotoxic T lymphocytes (CTLs). Over the past 25 years, substantial evidence has emerged for an ‘exogenous’ pathway for loading MHC class I molecules. Dendritic cells are potent stimulators of T-cell responses and can induce CD8 + CTLs by phagocytosis of dead tumor or virus-infected cells. Here, Marie Larsson and colleagues discuss the role of dendritic cells in stimulating MHC class I-restricted T-cell responses by exogenous routes.
ISSN:1471-4906
1471-4981
DOI:10.1016/S1471-4906(01)01860-9