Disease model: dissecting the pathogenesis of the measles virus

Host–pathogen interactions of measles virus (MV), a leading cause of childhood mortality worldwide, are still poorly understood. Using transgenic mice that express the human MV receptor CD46, we generated models to study the pathogenesis of MV infection of the central nervous system (CNS) and immune...

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Bibliographic Details
Published in:Trends in Molecular Medicine 2001-02, Vol.7 (2), p.85-88
Main Authors: Patterson, John B, Manchester, Marianne, Oldstone, Michael B.A
Format: Article
Language:English
Subjects:
Animal model
Animals
Central Nervous System - virology
CNS disease
Hippocampus - cytology
Humans
Immunosuppression
Measels virus
Measles virus
Measles virus - pathogenicity
Mice
Mice, Knockout
Mice, Transgenic
Transgenic mice
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Summary:Host–pathogen interactions of measles virus (MV), a leading cause of childhood mortality worldwide, are still poorly understood. Using transgenic mice that express the human MV receptor CD46, we generated models to study the pathogenesis of MV infection of the central nervous system (CNS) and immune system. CNS infection in CD46 transgenic mice allows replication and spread throughout neurons, inflammation, and ultimately death of the animals. CD46-transgenic mice can also be used to study immunosuppression, a hallmark of measles. Together with mouse knockout technology and a system for generating recombinant MVs, CD46 transgenic mice will ultimately lead to a better understanding of both viral and host factors contributing to disease.
ISSN:1471-4914
1471-499X
DOI:10.1016/S1471-4914(01)01918-9