Evaluation of Critical Binder Properties Affecting the Compactibility of Binary Mixtures

• Published in: Drug development and industrial pharmacy 2001, Vol.27 (3), p.181-194
• Main Authors: Mattsson, Sofia, Nyström, Christer
• Format: Article
• Language: English
• Subjects: Binder; Biological and medical sciences; Compaction; Deformability; General pharmacology; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Porosity; Sodium Bicarbonate; Tablet; Tablet strength; Tablets; Technology, Pharmaceutical; Tensile Strength
• ISSN: 0363-9045; 1520-5762
• DOI: 10.1081/DDC-100000236

The aim of this study was to identify essential physical and mechanical properties of various binders and to investigate their influence on the tensile strength and porosity of tablets made from binary mixtures with sodium bicarbonate. The binders were characterized according to axial and radial tensile strength after compression into tablets, yield pressure and minimum porosity during compression, and elastic recovery after compression. The addition of a binder generally resulted in an increase in the tensile strength and a decrease in the porosity of the sodium bicarbonate tablets. The location of the binder in the voids between the sodium bicarbonate particles thus decreasing the porosity of the tablet seemed to be an important consideration. Consequently, the addition of binders with a low yield pressure value and a relatively small elastic recovery value (e.g., polyethylene glycol 3000 and polyvinylpyrrolidone) resulted in tablets of low porosity and high tensile strength, especially in the axial direction. The tensile strength of the pure binder also seemed to be important, especially for binders with a lower degree of deformability (e.g., microcrystalline cellulose and pregelatinised starch). The results also indicated the value of using both axial and radial tensile strength measurements in assessing the effect of a dry binder and showed that the importance of different binder properties varied according to the direction of the tablet strength measurements. The results demonstrated that the applied characteristics of the binders used in this study may serve as a useful tool in evaluating the effectiveness of binders.