Modulating the immune response with dendritic cells and their growth factors

Different subsets of dendritic cells (DCs) appear to play a role in determining the specific cytokines secreted by T helper (Th) cells. A model is proposed that links together factors such as the pathogen, microenvironment, DCs and T cells in a mechanism that results in a flexible determination of T...

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Bibliographic Details
Published in:Trends in Immunology 2001, Vol.22 (1), p.41-47
Main Authors: Pulendran, Bali, Banchereau, Jacques, Maraskovsky, Eugene, Maliszewski, Charles
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - physiology
Animals
Cell Differentiation - immunology
Cell Lineage - immunology
Dendritic Cells - classification
Dendritic Cells - cytology
Dendritic Cells - immunology
Dentric cells
FIt3-ligand
G-CSF
GM-CSF
Growth Substances - immunology
Humans
Th1/Th2
Vaccines
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Summary:Different subsets of dendritic cells (DCs) appear to play a role in determining the specific cytokines secreted by T helper (Th) cells. A model is proposed that links together factors such as the pathogen, microenvironment, DCs and T cells in a mechanism that results in a flexible determination of T-cell polarization.
ISSN:1471-4906
1471-4981
DOI:10.1016/S1471-4906(00)01794-4