Macrophage activation in rat models of inflammation and arthritis: Systemic activation precedes arthritis induction and progression

The association between the induction and progression of adjuvant‐induced arthritis (AA) and the development of synovial and systemic macrophage activation was assessed by studying the temporal development of these parameters in a rat model. Rats with AA developed significant edema of the uninjected...

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Bibliographic Details
Published in:Arthritis and rheumatism 1986-09, Vol.29 (9), p.1122-1130
Main Authors: Johnson, William J., Muirhead, Katharine A., Meunier, Paul C., Votta, Bart J., Schmitt, Thomas C., Dimartino, Michael J., Hanna, Nabil
Format: Article
Language:English
Subjects:
Animals
Arthritis - immunology
Biological and medical sciences
Cells, Cultured
Dinoprostone
Disease Models, Animal
Diseases of the osteoarticular system
Inflammation - immunology
Inflammatory joint diseases
Macrophage Activation
Macrophages - metabolism
Male
Medical sciences
Monocytes - immunology
Prostaglandins E - metabolism
Rats
Rats, Inbred Lew
Spleen - cytology
Synovial Membrane - immunology
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Summary:The association between the induction and progression of adjuvant‐induced arthritis (AA) and the development of synovial and systemic macrophage activation was assessed by studying the temporal development of these parameters in a rat model. Rats with AA developed significant edema of the uninjected hind leg beginning 10 days post‐adjuvant injection, with progressive increases in edema continuing through day 17. Several parameters of macrophage activation, including the enhanced ability to secrete interleukin‐1 and prostaglandin E2, kill tumor cells, accumulate fluorescent cyanine dyes, emigrate into the peritoneal cavity and synovium, and express Ia antigen, as well as the decreased ability to secrete superoxide anion, were associated temporally with the development of the arthritic lesion. In addition to the temporal association between macrophage activation and development of arthritis, a positive correlation between macrophage activation and arthritis induction was seen with the use of synthetic adjuvants at arthritogenic and nonarthritogenic doses. These data taken together suggest that induction and progression of AA in rats is associated with both systemic (blood, spleen, and peritoneal cavity) and local (synovium) macrophage activation.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780290910