Abnormal sympathovagal balance in men with fibromyalgia

OBJECTIVE: It is possible that there are differences in clinical manifestations between men and women with fibromyalgia syndrome (FM), especially in autonomic dysfunction; we assessed the interaction between the sympathetic and parasympathetic systems in postural change in men with FM using power sp...

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Bibliographic Details
Published in:Journal of rheumatology 2001-03, Vol.28 (3), p.581-589
Main Authors: COHEN, Hagit, NEUMANN, Lily, ALHOSSHLE, Ali, KOTLER, Moshe, ABU-SHAKRA, Mahmoud, BUSKILA, Dan
Format: Article
Language:English
Subjects:
Adult
Anxiety - physiopathology
Biological and medical sciences
Depression - physiopathology
Diseases of the osteoarticular system
Fibromyalgia - diagnosis
Fibromyalgia - physiopathology
Fourier Analysis
Heart Rate - physiology
Humans
Male
Medical sciences
Middle Aged
Miscellaneous. Osteoarticular involvement in other diseases
Parasympathetic Nervous System - physiopathology
Sympathetic Nervous System - physiopathology
Vagus Nerve - physiopathology
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Summary:OBJECTIVE: It is possible that there are differences in clinical manifestations between men and women with fibromyalgia syndrome (FM), especially in autonomic dysfunction; we assessed the interaction between the sympathetic and parasympathetic systems in postural change in men with FM using power spectral analysis (PSA) of heart rate variability (HRV), and investigated the pathogenesis of the orthostatic intolerance. METHODS: We studied 19 men with FM and 19 controls matched for age and sex. A high resolution electrocardiogram was obtained in supine and standing postures during complete rest. Spectral analysis of R-R intervals was done by the fast Fourier transform algorithm. RESULTS: PSA of HRV revealed that men with FM at rest are characterized by sympathetic hyperactivity and concomitantly reduced parasympathetic activity. During postural changes, male patients demonstrated an abnormal sympathovagal response. These results provide the physiological basis for the orthostatic intolerance in men with FM. CONCLUSION: This report of autonomic dysfunction in men with FM revealed an abnormal autonomic response to orthostatic stress. This abnormality may have implications regarding the symptoms of FM.
ISSN:0315-162X
1499-2752