Novel periodontal drug delivery system for treatment of periodontitis

A conceptually novel periodontal drug delivery system (DDS) is described that is intended for treatment of microbial infections associated with periodontitis. The DDS is a composite wafer with surface layers possessing adhesive properties, while the bulk layer consists of antimicrobial agents, biode...

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Bibliographic Details
Published in:Journal of controlled release 2001-04, Vol.71 (3), p.251-259
Main Authors: Bromberg, Lev E, Buxton, Debra K, Friden, Phillip M
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial agents
Biological and medical sciences
Cellulose - analogs & derivatives
Cross-Linking Reagents
Drug Delivery Systems
Excipients
General pharmacology
Gingiva - metabolism
Lactic Acid
Medical sciences
Microscopy, Electron, Scanning
Penicillin G - administration & dosage
Penicillin G - therapeutic use
Penicillins - administration & dosage
Penicillins - therapeutic use
Peridontitis
Periodontitis - drug therapy
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Poly(lactic acid- co-glycolic acid)
Polyethylene Glycols
Polyglycolic Acid
Polymers
Silver nitrate
Silver Nitrate - administration & dosage
Silver Nitrate - chemistry
Sustained release
Tetracycline - administration & dosage
Tetracycline - therapeutic use
Wafer
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Description
Summary:A conceptually novel periodontal drug delivery system (DDS) is described that is intended for treatment of microbial infections associated with periodontitis. The DDS is a composite wafer with surface layers possessing adhesive properties, while the bulk layer consists of antimicrobial agents, biodegradable polymers, and matrix polymers. The wafers contain poly(lactic- co-glycolic acid) as the main bioerodible component used in the bulk layer and ethyl cellulose applied as a matrix polymer enabling diffusion-controlled release. Starch and other polymers in combination with AgNO 3 serve as coatings adhesive to the teeth. In vitro experiments demonstrate that the wafers are capable of zero-order release of antimicrobial agents such as silver nitrate, benzylpenicillin, and tetracycline, for over 4 weeks.
ISSN:0168-3659
1873-4995
DOI:10.1016/S0168-3659(01)00226-7