Augmentation of macrophage functions by an aqueous extract isolated from Platycodon grandiflorum

Platycodon grandiflorum has been claimed to have a wide range of health benefits, which include immunostimulation and antitumor activity. The associated biological mechanisms are unclear; however, of the wide diversity of effects, it is believed that their activities may be exerted through several p...

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Bibliographic Details
Published in:Cancer letters 2001-05, Vol.166 (1), p.17-25
Main Authors: Choi, Chul Yung, Kim, Ji Young, Kim, Young Sup, Chung, Young Chul, Hahm, Kyung-Soo, Jeong, Hye Gwang
Format: Article
Language:English
Subjects:
Activation
Animals
Antineoplastic agents
Biological and medical sciences
Cell Adhesion - drug effects
Cell Division - drug effects
Cell Survival - drug effects
Cells, Cultured
Chemotherapy
Cytokine
Cytokines - biosynthesis
Cytokines - genetics
Drug Contamination
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - pharmacology
Female
Immunomodulators
Lipopolysaccharides - analysis
Macrophage Activation - drug effects
Macrophages
Macrophages - drug effects
Macrophages - immunology
Medical sciences
Mice
Mice, Inbred BALB C
Nitric Oxide - biosynthesis
Phagocytosis - drug effects
Pharmacology. Drug treatments
Platycodon grandiflorum
RNA, Messenger - biosynthesis
Sarcoma 180 - pathology
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Summary:Platycodon grandiflorum has been claimed to have a wide range of health benefits, which include immunostimulation and antitumor activity. The associated biological mechanisms are unclear; however, of the wide diversity of effects, it is believed that their activities may be exerted through several potent effector cells such as macrophages. Therefore, the effects of an aqueous extract from the root of P. grandiflorum (Changkil: CK) on mouse peritoneal macrophage function were investigated. It was found that CK stimulated macrophage proliferation, spreading ability, phagocytosis, cytostatic activity, and nitric oxide production in a dose-dependent manner, and that the production of cytokines such as TNF-α, IL-1β and IL-6 were similarly increased. CK significantly affected secretion at concentrations greater than 10 μg/ml; its maximal effects were at the concentration of 100 μg/ml. Reverse transcription-polymerase chain reaction showed that CK increased the appropriate cytokine mRNAs. These results suggest that CK is a potent enhancer of macrophage function.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(01)00440-2