Peanut lectin binding in breast carcinoma: Lack of correlation with estrogen receptor content

Previous reports have shown binding of peanut agglutinin (PNA) by immunoperoxidase techniques in normal, benign proliferative, and malignant breast epithelia. Correlation of binding with maturity, secretory activity, hormonal milieu, and tissue hormone receptor content has been described. To investi...

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Bibliographic Details
Published in:Cancer 1986-11, Vol.58 (9), p.2046-2051
Main Authors: Stanley, Michael W., Kiang, David T., Sibley, Richard K.
Format: Article
Language:English
Subjects:
Arachis
Biological and medical sciences
Breast Neoplasms - metabolism
Female
Gynecology. Andrology. Obstetrics
Histocytochemistry
Humans
Immunoenzyme Techniques
Lectins - metabolism
Mammary gland diseases
Medical sciences
Peanut Agglutinin
Plant Lectins
Receptors, Estrogen - metabolism
Staining and Labeling
Tumors
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Summary:Previous reports have shown binding of peanut agglutinin (PNA) by immunoperoxidase techniques in normal, benign proliferative, and malignant breast epithelia. Correlation of binding with maturity, secretory activity, hormonal milieu, and tissue hormone receptor content has been described. To investigate the relationship between PNA staining by the avidin‐biotin complex technique and estrogen receptor (ER) content, 79 breast tumors of different types and known tissue ER content were studied. Thirty‐eight of 50 ER‐positive cases were PNA‐positive. Twenty of 29 ER‐negative cases were PNA‐positive. Statistical analysis shows the two factors to be independent (0.5 < P < 0.9). The literature on blood group antigens in breast carcinoma and histochemical applications of PNA is reviewed.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19861101)58:9<2046::AID-CNCR2820580915>3.0.CO;2-Y