Chronic diuretic effect of the water extract of Spergularia purpurea in normal rats

The purpose of this study was to examine the chronic diuretic effect of the water extract of the whole plant of Spergularia purpurea (SP) at different doses (100, 200 and 400 mg/kg) in normal rats. Daily oral administration of the water extract was tested for 4 weeks. Urinary water and electrolytes...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2001-05, Vol.75 (2), p.219-223
Main Authors: Jouad, H., Lacaille-Dubois, M.A., Eddouks, M.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chlorides - chemistry
Diuretic activity
Diuretics - pharmacology
Dose-Response Relationship, Drug
Electrolytes excretion
General pharmacology
Glomerular Filtration Rate - drug effects
Hydrogen-Ion Concentration
Magnoliopsida - chemistry
Male
Medical sciences
Osmolar Concentration
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - chemistry
Plant Extracts - pharmacology
Potassium - analysis
Potassium - urine
Rats
Rats, Wistar
Sodium - urine
Spergularia purpurea
Urine - chemistry
Water - chemistry
Water excretion
Water extract
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Summary:The purpose of this study was to examine the chronic diuretic effect of the water extract of the whole plant of Spergularia purpurea (SP) at different doses (100, 200 and 400 mg/kg) in normal rats. Daily oral administration of the water extract was tested for 4 weeks. Urinary water and electrolytes excretion were determined weekly. Oral administration of the water extract at different doses produced a significant and dose-dependent diuresis and increase in electrolytes excretion. The highest dose (400 mg/kg) of the water extract of SP enhanced urine output from 7.15±0.42 ml/24 h at the start to 23.01±0.75 ml/24 h after 4 weeks (p
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(01)00193-3