Immunoblastic lymphadenopathy, angioimmunoblastic lymphadenopathy, and IBL‐like T‐cell lymphoma: A spectrum of T‐cell neoplasia

• Published in: Cancer 1986-11, Vol.58 (10), p.2224-2232
• Main Authors: Watanabe, Shaw, Sato, Yuichi, Shimoyama, Masanori, Minato, Keisuke, Shimosato, YUKIO
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface - analysis; Biological and medical sciences; Female; Hematologic and hematopoietic diseases; Humans; Immunoblastic Lymphadenopathy - classification; Immunoblastic Lymphadenopathy - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymph Nodes - pathology; Lymphoma, Non-Hodgkin - classification; Lymphoma, Non-Hodgkin - pathology; Lymphoproliferative Disorders - classification; Lymphoproliferative Disorders - pathology; Male; Medical sciences; Middle Aged; Prognosis; T-Lymphocytes - classification; T-Lymphocytes - pathology
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/1097-0142(19861115)58:10<2224::AID-CNCR2820581011>3.0.CO;2-3

Thirty cases of immunologically determined and histologically diagnosed immunoblastic lymphadenopathy (IBL), angioimmunoblastic lymphadenopathy (AILD), and IBL‐like T‐cell lymphoma were clinicopathologically reviewed. Clinical manifestations and laboratory findings did not reveal significant differences in these three groups. IBL, AILD, and IBL‐like T‐cell lymphoma showed a spectrum of histologic changes, in which proliferation of pale cells was a critical diagnostic point for the histologic malignancy. Immunostaining for their subsets revealed that 3 of 21 cases showed T4+ phenotype and the remaining 19 cases showed T8+ phenotype. Three of seven immunohistochemically determined T8+ cases simultaneously expressed Leu7+ phenotype. The latter cells were consistent with large granular lymphocytes in one case, but no clinicopathological differences from the other T8+ cases were present. IBL and AILD were considered to be T‐cell malignancies, which show a spectrum of histologic features from T‐cell dysplasia to peripheral T‐cell lymphoma (IBL‐like T‐cell lymphoma). Despite intensive chemotherapy, prognosis was poor in T8+ cases of which half of the patients died within 1 year. T4+ cases showed better prognosis, but a higher incidence of synchronous second primary cancers was recognized.