Prognostic importance of progesterone and estrogen receptors in cancer of the uterine cervix

Tissue levels of cytosolic estrogen receptors (ERc) and progesterone receptors (PRc) have been shown to have prognostic meaning in hormonally responsive cancers arising in the breast and endometrium. Although carcinomas of the uterine cervix rarely respond to hormonal manipulation, the normal cervic...

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Bibliographic Details
Published in:Cancer 1986-10, Vol.58 (8), p.1709-1713
Main Authors: Potish, Roger A., Twiggs, Leo B., Adcock, Leon L., Prem, Konald A., Savage, John E., Leung, Benjamin S.
Format: Article
Language:English
Subjects:
Adenocarcinoma - physiopathology
Biological and medical sciences
Carcinoma, Squamous Cell - physiopathology
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Lymphatic Metastasis
Medical sciences
Menopause
Prognosis
Receptors, Estrogen - physiology
Receptors, Progesterone - physiology
Tumors
Uterine Cervical Neoplasms - physiopathology
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Summary:Tissue levels of cytosolic estrogen receptors (ERc) and progesterone receptors (PRc) have been shown to have prognostic meaning in hormonally responsive cancers arising in the breast and endometrium. Although carcinomas of the uterine cervix rarely respond to hormonal manipulation, the normal cervical stroma and epithelia contain ERc and PRc. To study the prognostic value of these receptors, 65 cervical carcinomas for ERcand PRcwere assayed before initiation of surgical or radiation therapy. In premenopausal women, logistic models demonstrated that clinical stage, surgical stage, and receptor level independently predict survival. If confirmed in further studies, ERc and PRc may prove to be useful prognostic factors in the management of cervical carcinomas.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19861015)58:8<1709::AID-CNCR2820580822>3.0.CO;2-B