A Moderate Interaction of Maltosyl-α-cyclodextrin with Caco-2 Cells in Comparison with the Parent Cyclodextrin

The cytotoxicity of maltosyl-α-cyclodextrin (G2-α-CyD) and maltosyl-β-cyclodextrin (G2-β-CyD) toward Caco-2 cells was compared with that of natural α-cyclodextrin (α-CyD), β-cyclodextrin (β-CyD) and γ-cyclodextrin (γ-CyD). The degree of increase in cytotoxicity was dependent on the CyD’s type and th...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2001, Vol.24(4), pp.395-402
Main Authors: ONO, Naomi, ARIMA, Hidetoshi, HIRAYAMA, Fumitoshi, UEKAMA, Kaneto
Format: Article
Language:English
Subjects:
1,2-Dipalmitoylphosphatidylcholine
Biological and medical sciences
branched cyclodextrin
Caco-2 cell
Caco-2 Cells
Cell Survival - drug effects
Cyclodextrins - pharmacology
cytotoxicity
Electric Conductivity
Electrophysiology
General pharmacology
Humans
Lipid Metabolism
Lipids - chemistry
Maltose - analogs & derivatives
maltosyl-α-cyclodextrin
maltosyl-β-cyclodextrin
Medical sciences
Membranes, Artificial
Neoplasm Proteins - chemistry
Neoplasm Proteins - metabolism
Pharmaceutical technology. Pharmaceutical industry
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Surface Tension
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Summary:The cytotoxicity of maltosyl-α-cyclodextrin (G2-α-CyD) and maltosyl-β-cyclodextrin (G2-β-CyD) toward Caco-2 cells was compared with that of natural α-cyclodextrin (α-CyD), β-cyclodextrin (β-CyD) and γ-cyclodextrin (γ-CyD). The degree of increase in cytotoxicity was dependent on the CyD’s type and the concentration: the cytotoxicity of CyDs at the same concentration increased in the order of γ-CyD
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.24.395