Notch pathway: Making sense of Suppressor of Hairless

Suppressor of Hairless (Su(H)) is a DNA-binding protein component of the Notch signalling pathway, thought to be required, with a fragment of the Notch receptor, for target gene activation. Recent studies show that this is only one side of the story: target gene enhancers may be regulated by Su(H) i...

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Bibliographic Details
Published in:Current biology 2001-03, Vol.11 (6), p.R217-R221
Main Authors: Bray, Sarah, Furriols, Marc
Format: Article
Language:English
Subjects:
Animals
Basic Helix-Loop-Helix Transcription Factors
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Drosophila Proteins
Enhancer Elements, Genetic
Gene Expression Regulation
Helix-Loop-Helix Motifs
Insect Proteins - genetics
Membrane Proteins - metabolism
Notch protein
Nuclear Proteins - genetics
Receptors, Notch
Repressor Proteins - genetics
Repressor Proteins - metabolism
Signal Transduction - physiology
Suppressor of Hairless protein
Transcriptional Activation
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Summary:Suppressor of Hairless (Su(H)) is a DNA-binding protein component of the Notch signalling pathway, thought to be required, with a fragment of the Notch receptor, for target gene activation. Recent studies show that this is only one side of the story: target gene enhancers may be regulated by Su(H) in a variety of different ways.
ISSN:0960-9822
1879-0445
DOI:10.1016/S0960-9822(01)00109-9