[ 18F]Fluoride from a small cyclotron for the routine synthesis of [ 18F]2-Fluoro-2-deoxy- d-glucose

[ 18F]Fluoride was produced via the 18O (p, n) 18F reaction using a low volume stainless steel 18O-water target in a small cyclotron. The average 18F production rate for 60 runs was about 720 μCi/μA-min. A typical bombardment time of 20 min produced 120 mCi of 18F-fluoride. [ 18F]2-Fluoro-2-deoxy- d...

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Bibliographic Details
Published in:International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes Applied radiation and isotopes, 1986, Vol.37 (5), p.397-401
Main Authors: DeJesus, O.T., Martin, J.A., Yasillo, N.J., Gatley, S.J., Cooper, M.D.
Format: Article
Language:English
Subjects:
Blood Glucose - metabolism
Deoxy Sugars - chemical synthesis
Deoxyglucose - analogs & derivatives
Deoxyglucose - chemical synthesis
Fluorine
Fluorodeoxyglucose F18
Humans
Particle Accelerators
Radioisotopes
Tomography, Emission-Computed
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Summary:[ 18F]Fluoride was produced via the 18O (p, n) 18F reaction using a low volume stainless steel 18O-water target in a small cyclotron. The average 18F production rate for 60 runs was about 720 μCi/μA-min. A typical bombardment time of 20 min produced 120 mCi of 18F-fluoride. [ 18F]2-Fluoro-2-deoxy- d-glucose ([ 18F]2FDG) was prepared using the procedure developed by Tewson [ J. Nucl. Med. 24, 718 (1983)] involving a protected cyclic sulfate glucose derivative as precursor. The routine synthesis and quality testing of [ 18F]2FDG required 1 h and, typically, yields of 30–35 mCi of > 95% HPLC-pure product were obtained.
ISSN:0883-2889
DOI:10.1016/0883-2889(86)90095-X