Apoptosis-inducing activity of high molecular weight fractions of tea extracts

High molecular weight fractions of green tea, black tea, oolong tea, and pu-erh tea were found to induce apoptosis in human monoblastic leukemia U937 cells by examination of their ability to inhibit cell proliferation and to induce apoptotic body formation and DNA ladder formation. These tea fractio...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2001-02, Vol.65 (2), p.459-462
Main Authors: Hayakawa, S. (Shizuoka Prefectural Univ. (Japan)), Kimura, T, Saeki, K, Koyama, Y, Aoyagi, Y, Noro, T, Nakamura, Y, Isemura, M
Format: Article
Language:English
Subjects:
APOPTOSIS
Apoptosis - drug effects
Biological and medical sciences
CARCINOMA
Catechin - analogs & derivatives
Catechin - pharmacology
chemoprevention
DNA Fragmentation - drug effects
epigallocatechin gallate
EXTRACTS
General pharmacology
Humans
Medical sciences
Molecular Weight
NEOPLASMS
Neoplasms - prevention & control
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - chemistry
Plant Extracts - pharmacology
stomach cancer
STOMACH DISEASES
Stomach Neoplasms - diet therapy
Stomach Neoplasms - pathology
TEA
Tea - chemistry
Tumor Cells, Cultured
U937 Cells
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Summary:High molecular weight fractions of green tea, black tea, oolong tea, and pu-erh tea were found to induce apoptosis in human monoblastic leukemia U937 cells by examination of their ability to inhibit cell proliferation and to induce apoptotic body formation and DNA ladder formation. These tea fractions were also shown to induce apoptosis in stomach cancer MKN-45 cells. In addition to known antitumor-promoting activity of tea high molecular weight fractions, their apoptosis-inducing activity may contribute to cancer chemopreventive effects of tea.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.65.459