Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid

Salvia officinalis L. leaves, obtained from four plant populations of different origin, were investigated for their topical anti-inflammatory properties. The n-hexane and the chloroform extracts dose-dependently inhibited the Croton oil-induced ear oedema in mice, the chloroform extracts being the m...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2001-05, Vol.75 (2), p.125-132
Main Authors: Baricevic, D., Sosa, S., Della Loggia, R., Tubaro, A., Simonovska, B., Krasna, A., Zupancic, A.
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Anti-inflammatory activity
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Biological and medical sciences
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
General pharmacology
Lamiaceae
Lamiaceae - chemistry
Male
Mass Spectrometry
Medical sciences
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant extracts
Plant Leaves - chemistry
Salvia officinalis
Spectrophotometry, Ultraviolet
Triterpenes - pharmacology
Ursolic Acid
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Summary:Salvia officinalis L. leaves, obtained from four plant populations of different origin, were investigated for their topical anti-inflammatory properties. The n-hexane and the chloroform extracts dose-dependently inhibited the Croton oil-induced ear oedema in mice, the chloroform extracts being the most active. By contrast, the methanol extracts showed a very low effect and the essential oil was inactive. Chemical and pharmacological investigation of the most potent chloroform extract, issued from an autochthonous sage population grown in the submediterranean climatic region of Slovenia, revealed ursolic acid as the main component involved in its anti-inflammatory activity. The anti-inflammatory effect of ursolic acid (ID 50=0.14 μMoles/cm 2) was two fold more potent than that of indomethacin (ID 50=0.26 μMoles/cm 2), which was used as a reference non-steroidal anti-inflammatory drug (NSAID). The content of ursolic acid in sage and sage-based remedies for the topical treatment of inflammatory diseases is proposed as a parameter for quality control purposes.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(00)00396-2