AHPATININS, NEW ACID PROTEASE INHIBITORS CONTAINING 4-AMINO-3-HYDROXY-5-PHENYLPENTANOIC ACID

A soil isolate, Streptomyces sp. WK-142, was found to produce new acid protease inhibitors, ahpatinins A, B, D, E, F and G active against pepsin and renin. Ahpatinin C was found to be identical with pepstatin A. The structure determinations were based on mass spectral data. Four of the compounds con...

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Bibliographic Details
Published in:Journal of antibiotics 1986, Vol.39(8), pp.1079-1085
Main Authors: OMURA, SATOSHI, IMAMURA, NOBUTAKA, KAWAKITA, KAZUHITO, MORI, YOKO, YAMAZAKI, YUKIKO, MASUMA, ROKUROU, TAKAHASHI, YOKO, TANAKA, HARUO, HUANG, LEE-YUAN, WOODRUFF, H. BOYD
Format: Article
Language:English
Subjects:
Amino Acids - analysis
Aspartic Acid Endopeptidases
Biological and medical sciences
Biotechnology
Chemical Phenomena
Chemistry
Endopeptidases
Fundamental and applied biological sciences. Psychology
General pharmacology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Mass Spectrometry
Medical sciences
Oligopeptides - isolation & purification
Other active biomolecules
Pepsin A - antagonists & inhibitors
Pepstatins - isolation & purification
Pepstatins - pharmacology
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Production of active biomolecules
Protease Inhibitors
Renin - antagonists & inhibitors
Streptomyces - classification
Streptomyces - metabolism
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Summary:A soil isolate, Streptomyces sp. WK-142, was found to produce new acid protease inhibitors, ahpatinins A, B, D, E, F and G active against pepsin and renin. Ahpatinin C was found to be identical with pepstatin A. The structure determinations were based on mass spectral data. Four of the compounds contain the unusual amino acid, 4-amino-3-hydroxy-5-phenylpentanoic acid as a building component.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.39.1079