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Augmentation of respiratory sinus arrhythmia in response to progressive hypercapnia in conscious dogs
1 First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya 466-8550; and 2 Third Department of Internal Medicine, Nagoya City University Medical School, Nagoya 467-8601, Japan Respiratory sinus arrhythmia (RSA) may serve to enhance pulmonary gas exchange efficiency by ma...
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| Published in: | American journal of physiology. Heart and circulatory physiology 2001-05, Vol.280 (5), p.H2336-H2341 |
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| cites | cdi_FETCH-LOGICAL-c471t-5e576cb78537d7d9af4885135fb5b7bf05b7fdfc6cf0fc39c460270230e9b3413 |
| container_end_page | H2341 |
| container_issue | 5 |
| container_start_page | H2336 |
| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 280 |
| creator | Yasuma, Fumihiko Hayano, Jun-Ichiro |
| description | 1 First Department of Internal Medicine, Nagoya University
School of Medicine, Nagoya 466-8550; and 2 Third Department
of Internal Medicine, Nagoya City University Medical School, Nagoya
467-8601, Japan
Respiratory sinus arrhythmia
(RSA) may serve to enhance pulmonary gas exchange efficiency by
matching pulmonary blood flow with lung volume within each respiratory
cycle. We examined the hypothesis that RSA is augmented as an active
physiological response to hypercapnia. We measured electrocardiograms
and arterial blood pressure during progressive hypercapnia in conscious
dogs that were prepared with a permanent tracheostomy and an implanted
blood pressure telemetry unit. The intensity of RSA was assessed
continuously as the amplitude of respiratory fluctuation of heart rate
using complex demodulation. In a total of 39 runs of hypercapnia in 3 dogs, RSA increased by 38 and 43% of the control level when minute
ventilation reached 10 and 15 l/min, respectively ( P < 0.0001 for both), and heart rate and mean arterial pressure showed no
significant change. The increases in RSA were significant even after
adjustment for the effects of increased tidal volume, respiratory rate,
and respiratory fluctuation of arterial blood pressure
( P |
| doi_str_mv | 10.1152/ajpheart.2001.280.5.h2336 |
| format | article |
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School of Medicine, Nagoya 466-8550; and 2 Third Department
of Internal Medicine, Nagoya City University Medical School, Nagoya
467-8601, Japan
Respiratory sinus arrhythmia
(RSA) may serve to enhance pulmonary gas exchange efficiency by
matching pulmonary blood flow with lung volume within each respiratory
cycle. We examined the hypothesis that RSA is augmented as an active
physiological response to hypercapnia. We measured electrocardiograms
and arterial blood pressure during progressive hypercapnia in conscious
dogs that were prepared with a permanent tracheostomy and an implanted
blood pressure telemetry unit. The intensity of RSA was assessed
continuously as the amplitude of respiratory fluctuation of heart rate
using complex demodulation. In a total of 39 runs of hypercapnia in 3 dogs, RSA increased by 38 and 43% of the control level when minute
ventilation reached 10 and 15 l/min, respectively ( P < 0.0001 for both), and heart rate and mean arterial pressure showed no
significant change. The increases in RSA were significant even after
adjustment for the effects of increased tidal volume, respiratory rate,
and respiratory fluctuation of arterial blood pressure
( P < 0.001). These observations indicate that
increased RSA during hypercapnia is not the consequence of altered
autonomic balance or respiratory patterns and support the hypothesis
that RSA is augmented as an active physiological response to hypercapnia.
autonomic nervous system; heart rate variability; blood pressure; central chemostimulation; complex demodulation</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.2001.280.5.h2336</identifier><identifier>PMID: 11299239</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Arrhythmia, Sinus - physiopathology ; Autonomic Nervous System - physiology ; Blood Pressure - physiology ; Chemoreceptor Cells - physiology ; Consciousness ; Dogs ; Heart Rate - physiology ; Hypercapnia - physiopathology ; Respiration</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2001-05, Vol.280 (5), p.H2336-H2341</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-5e576cb78537d7d9af4885135fb5b7bf05b7fdfc6cf0fc39c460270230e9b3413</citedby><cites>FETCH-LOGICAL-c471t-5e576cb78537d7d9af4885135fb5b7bf05b7fdfc6cf0fc39c460270230e9b3413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11299239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yasuma, Fumihiko</creatorcontrib><creatorcontrib>Hayano, Jun-Ichiro</creatorcontrib><title>Augmentation of respiratory sinus arrhythmia in response to progressive hypercapnia in conscious dogs</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>1 First Department of Internal Medicine, Nagoya University
School of Medicine, Nagoya 466-8550; and 2 Third Department
of Internal Medicine, Nagoya City University Medical School, Nagoya
467-8601, Japan
Respiratory sinus arrhythmia
(RSA) may serve to enhance pulmonary gas exchange efficiency by
matching pulmonary blood flow with lung volume within each respiratory
cycle. We examined the hypothesis that RSA is augmented as an active
physiological response to hypercapnia. We measured electrocardiograms
and arterial blood pressure during progressive hypercapnia in conscious
dogs that were prepared with a permanent tracheostomy and an implanted
blood pressure telemetry unit. The intensity of RSA was assessed
continuously as the amplitude of respiratory fluctuation of heart rate
using complex demodulation. In a total of 39 runs of hypercapnia in 3 dogs, RSA increased by 38 and 43% of the control level when minute
ventilation reached 10 and 15 l/min, respectively ( P < 0.0001 for both), and heart rate and mean arterial pressure showed no
significant change. The increases in RSA were significant even after
adjustment for the effects of increased tidal volume, respiratory rate,
and respiratory fluctuation of arterial blood pressure
( P < 0.001). These observations indicate that
increased RSA during hypercapnia is not the consequence of altered
autonomic balance or respiratory patterns and support the hypothesis
that RSA is augmented as an active physiological response to hypercapnia.
autonomic nervous system; heart rate variability; blood pressure; central chemostimulation; complex demodulation</description><subject>Animals</subject><subject>Arrhythmia, Sinus - physiopathology</subject><subject>Autonomic Nervous System - physiology</subject><subject>Blood Pressure - physiology</subject><subject>Chemoreceptor Cells - physiology</subject><subject>Consciousness</subject><subject>Dogs</subject><subject>Heart Rate - physiology</subject><subject>Hypercapnia - physiopathology</subject><subject>Respiration</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp1kM1u1DAURi0EotPCK6CwYZfUP-M4FquqorRSJTZlbTnOdeIqiYPtQPP2eJgByoKNLeuec_3pQ-g9wRUhnF7qx2UAHVJFMSYVbXDFq4EyVr9AuzynJeFMvkQ7zGpW1oTxM3Qe4yPGmIuavUZnhFApKZM7BFdrP8GcdHJ-LrwtAsTFBZ182Iro5jUWOoRhS8PkdOHmX3M_RyiSL5bg-_yO7jsUw7ZAMHqZj5jJjHE-653v4xv0yuoxwtvTfYG-3nx6uL4t7798vru-ui_NXpBUcsj5TCsazkQnOqntvml4zm9b3orW4nzazpraWGwNk2ZfYyowZRhky_aEXaAPx7052bcVYlKTiwbGUc-QsyghMK8byTMoj6AJPsYAVi3BTTpsimB16Fj97lgdOla5Y8XV7aHj7L47fbK2E3R_zVOpGbg8AoPrhx8ugFqGLTo_-n57tveflR__b9ys4_gAT-mP-sxUS2fZT9supDA</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>Yasuma, Fumihiko</creator><creator>Hayano, Jun-Ichiro</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010501</creationdate><title>Augmentation of respiratory sinus arrhythmia in response to progressive hypercapnia in conscious dogs</title><author>Yasuma, Fumihiko ; Hayano, Jun-Ichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-5e576cb78537d7d9af4885135fb5b7bf05b7fdfc6cf0fc39c460270230e9b3413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Arrhythmia, Sinus - physiopathology</topic><topic>Autonomic Nervous System - physiology</topic><topic>Blood Pressure - physiology</topic><topic>Chemoreceptor Cells - physiology</topic><topic>Consciousness</topic><topic>Dogs</topic><topic>Heart Rate - physiology</topic><topic>Hypercapnia - physiopathology</topic><topic>Respiration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yasuma, Fumihiko</creatorcontrib><creatorcontrib>Hayano, Jun-Ichiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yasuma, Fumihiko</au><au>Hayano, Jun-Ichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Augmentation of respiratory sinus arrhythmia in response to progressive hypercapnia in conscious dogs</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2001-05-01</date><risdate>2001</risdate><volume>280</volume><issue>5</issue><spage>H2336</spage><epage>H2341</epage><pages>H2336-H2341</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><abstract>1 First Department of Internal Medicine, Nagoya University
School of Medicine, Nagoya 466-8550; and 2 Third Department
of Internal Medicine, Nagoya City University Medical School, Nagoya
467-8601, Japan
Respiratory sinus arrhythmia
(RSA) may serve to enhance pulmonary gas exchange efficiency by
matching pulmonary blood flow with lung volume within each respiratory
cycle. We examined the hypothesis that RSA is augmented as an active
physiological response to hypercapnia. We measured electrocardiograms
and arterial blood pressure during progressive hypercapnia in conscious
dogs that were prepared with a permanent tracheostomy and an implanted
blood pressure telemetry unit. The intensity of RSA was assessed
continuously as the amplitude of respiratory fluctuation of heart rate
using complex demodulation. In a total of 39 runs of hypercapnia in 3 dogs, RSA increased by 38 and 43% of the control level when minute
ventilation reached 10 and 15 l/min, respectively ( P < 0.0001 for both), and heart rate and mean arterial pressure showed no
significant change. The increases in RSA were significant even after
adjustment for the effects of increased tidal volume, respiratory rate,
and respiratory fluctuation of arterial blood pressure
( P < 0.001). These observations indicate that
increased RSA during hypercapnia is not the consequence of altered
autonomic balance or respiratory patterns and support the hypothesis
that RSA is augmented as an active physiological response to hypercapnia.
autonomic nervous system; heart rate variability; blood pressure; central chemostimulation; complex demodulation</abstract><cop>United States</cop><pmid>11299239</pmid><doi>10.1152/ajpheart.2001.280.5.h2336</doi></addata></record> |
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| ispartof | American journal of physiology. Heart and circulatory physiology, 2001-05, Vol.280 (5), p.H2336-H2341 |
| issn | 0363-6135 1522-1539 |
| language | eng |
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| source | American Physiological Society Free |
| subjects | Animals Arrhythmia, Sinus - physiopathology Autonomic Nervous System - physiology Blood Pressure - physiology Chemoreceptor Cells - physiology Consciousness Dogs Heart Rate - physiology Hypercapnia - physiopathology Respiration |
| title | Augmentation of respiratory sinus arrhythmia in response to progressive hypercapnia in conscious dogs |
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