Cellular immune responses to HIV

The cellular immune response to the human immunodeficiency virus, mediated by T lymphocytes, seems strong but fails to control the infection completely. In most virus infections, T cells either eliminate the virus or suppress it indefinitely as a harmless, persisting infection. But the human immunod...

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Bibliographic Details
Published in:Nature (London) 2001-04, Vol.410 (6831), p.980-987
Main Authors: McMichael, Andrew J, Rowland-Jones, Sarah L
Format: Article
Language:English
Subjects:
AIDS Vaccines
Analysis
Animals
CD4 antigen
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - virology
CD8 antigen
CD8-Positive T-Lymphocytes - immunology
Cell-mediated cytotoxicity
Cells
Control
Cytotoxicity, Immunologic
HIV
HIV (Viruses)
HIV - immunology
HIV infection
HIV Infections - immunology
Human immunodeficiency virus
Humans
Immune response
Immune system
Immune Tolerance
Infections
Influence
Lymphocyte Activation
Lymphocytes
T cells
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Helper-Inducer - immunology
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Summary:The cellular immune response to the human immunodeficiency virus, mediated by T lymphocytes, seems strong but fails to control the infection completely. In most virus infections, T cells either eliminate the virus or suppress it indefinitely as a harmless, persisting infection. But the human immunodeficiency virus undermines this control by infecting key immune cells, thereby impairing the response of both the infected CD4+ T cells and the uninfected CD8+ T cells. The failure of the latter to function efficiently facilitates the escape of virus from immune control and the collapse of the whole immune system.
ISSN:0028-0836
1476-4687
DOI:10.1038/35073658