Assessment of the effect of revascularization early after CABG using ECG-gated perfusion single-photon emission tomography

• Published in: European Journal of Nuclear Medicine 2001-02, Vol.28 (2), p.230-239
• Main Authors: KUBO, Shigeto, TADAMURA, Eiji, KUDOH, Takashi, INUBUSHI, Masayuki, IKEDA, Tadashi, KOSHIJI, Takaaki, NISHIMURA, Kazunobu, KOMEDA, Masashi, TAMAKI, Nagara, KONISHI, Junji
• Format: Article
• Language: English
• Subjects: Aged; Biological and medical sciences; Coronary Artery Bypass; Coronary Circulation; Electrocardiography; Female; Gated Blood-Pool Imaging - methods; Hemodynamics - physiology; Humans; Male; Medical sciences; Middle Aged; Myocardial Revascularization; Radiopharmaceuticals; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon - methods
• ISSN: 0340-6997; 1619-7070; 1619-7089
• DOI: 10.1007/s002590000419

When an arterial graft is used, reversible perfusion defects on single-photon emission tomography (SPET) perfusion images are occasionally observed early after coronary artery bypass graft surgery (CABG), owing to the restricted flow capacity. The purpose of this study was to determine whether the functional information obtained with electrocardiography (ECG)-gated perfusion SPET could be helpful in evaluating the effect of revascularization early after CABG. Twenty-three patients (18 men and 5 women, mean age 65+/-9 years) underwent stress/re-injection thallium-201 ECG-gated SPET before and 4 weeks after CABG (13 with exercise and 10 with dipyridamole). Patency of all grafts was confirmed by coronary angiography 1 month after CABG. Cardiac functional data including the left ventricular ejection fraction (LVEF) and the transient ischaemic dilatation (TID) ratio were analysed using a commercially available automated program. The conventional stress and re-injection tomograms were interpreted by means of a five-point scoring system in a nine-segment model. Stress-induced reversible 201Tl perfusion defects were present in 64% of the myocardial segments bypassed by patent arterial grafts, in contrast to 42% of the myocardial segments bypassed by patent venous grafts (chi2=7.8, P=0.005). Of the 23 patients, 12 showed improvement in summed ischaemic scores (group 1), while 11 had no change or deterioration (group 2), although all grafts were patent on postoperative catheterization. The TID ratio improved in both group 1 and group 2 before and after CABG (1.14+/-0.13 vs 0.99+/-0.07, P=0.001 and 1.09+/-0.07 vs 0.94+/-0.05, P=0.002, respectively). However, LVEF did not significantly improve in group 1 or group 2 after CABG (42.5%+/-9.9% vs 47.5%+/-11.8%, and 52.1%+/-7.5% vs 53.1%+/-5.9%, respectively). Perfusion imaging or LVEF assessment is of limited value early after CABG. The TID ratio obtained with ECG-gated perfusion SPET may be a useful marker to evaluate the effect of revascularization early after surgery.