High-Performance Digital Image Analyzer for Quantitative Autoradiography

A digital image-processing system was developed for high–spatial resolution analysis of autoradiograms. The system uses a linear array of charge-coupled devices operating under computer control to scan and digitize autoradiograms into 512 × 512 matrices with 256 gray levels. Software was developed t...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 1986-10, Vol.6 (5), p.625-629
Main Authors: Lear, James L., Mido, Kenneth, Plotnick, Jeffrey, Muth, Russell
Format: Article
Language:English
Subjects:
Autoradiography - instrumentation
Biological and medical sciences
Image Processing, Computer-Assisted - instrumentation
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Miscellaneous. Technology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Software
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Description
Summary:A digital image-processing system was developed for high–spatial resolution analysis of autoradiograms. The system uses a linear array of charge-coupled devices operating under computer control to scan and digitize autoradiograms into 512 × 512 matrices with 256 gray levels. Software was developed to facilitate quantitative analysis of autoradiograms produced in single- and multiple-tracer studies. Because of the high output, linearity, and accuracy of the solid-state detectors, the system was found to digitize autoradiograms significantly more precisely and accurately than previously described video camera- or photomultiplier tube-based scanning densitometers.
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.1986.110