Co-administration of adenovirus vector expressing CTLA4-Ig prolongs transgene expression in the brain of mice sensitized with adenovirus

The duration of transgene expression in the brain is known to be shortened by previous sensitization to adenovirus. In order to prolong transgene expression, adenovirus vectors expressing CTLA4-Ig (AdCTLA), which blocks the B7-CD28 co-stimulatory signals required for T-cell activation, were used. Lo...

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Bibliographic Details
Published in:Brain research 2001-04, Vol.898 (2), p.272-280
Main Authors: Uchida, Tetsuya, Kajiwara, Koji, Ideguchi, Makoto, Yoshikawa, Koichi, Morioka, Jun, Suzuki, Michiyasu
Format: Article
Language:English
Subjects:
Abatacept
Adenoviridae - genetics
Adenoviridae - immunology
Adenoviridae Infections - genetics
Adenoviridae Infections - immunology
Adenovirus
Adenovirus vector
Animals
Antibodies - genetics
Antibodies - immunology
Antibodies - metabolism
Antigens, CD
Antigens, Differentiation - genetics
Antigens, Differentiation - immunology
beta-Galactosidase - genetics
beta-Galactosidase - immunology
beta-Galactosidase - metabolism
Biochemistry and metabolism
Biological and medical sciences
Brain
Brain - immunology
Brain - metabolism
Brain - virology
Central nervous system
CTLA-4 Antigen
CTLA4-Ig
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Viral - immunology
Gene transfer
Genes, Reporter - immunology
Genetic Therapy - adverse effects
Genetic Vectors - immunology
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - immunology
Immunoconjugates
Leukocytes - cytology
Leukocytes - immunology
Mice
Mice, Inbred C3H
Priming
Transgenes - genetics
Transgenes - immunology
Vertebrates: nervous system and sense organs
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Summary:The duration of transgene expression in the brain is known to be shortened by previous sensitization to adenovirus. In order to prolong transgene expression, adenovirus vectors expressing CTLA4-Ig (AdCTLA), which blocks the B7-CD28 co-stimulatory signals required for T-cell activation, were used. Local administration of AdCTLA into the brain suppressed both the cellular and humoral immune responses to adenovirus vectors, and prolonged the duration of transgene expression. AdCTLA may be an effective tool for repeated gene transfer.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(01)02194-1