The dynamics of CD4 + T-cell depletion in HIV disease

The size and composition of the CD4 + T-cell population is regulated by balanced proliferation of progenitor cells and death of mature progeny. After infection with the human immunodeficiency virus, this homeostasis is often disturbed and CD4 + T cells are instead depleted. Such depletion cannot res...

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Bibliographic Details
Published in:Nature (London) 2001-04, Vol.410 (6831), p.974-979
Main Author: McCune, Joseph M
Format: Article
Language:English
Subjects:
Animals
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes - cytology
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - virology
CD8-Positive T-Lymphocytes - immunology
Cell Death
Cells
Cellular biology
Disease Progression
HIV
HIV - immunology
HIV - pathogenicity
HIV - physiology
HIV Infections - immunology
HIV Infections - physiopathology
HIV Infections - virology
Human immunodeficiency virus
Humanities and Social Sciences
Humans
Immunology
Infections
Leukopoiesis
Lymphocyte Activation
Lymphoid Tissue - immunology
Lymphoid Tissue - virology
Models, Biological
multidisciplinary
review-article
Science
Science (multidisciplinary)
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Summary:The size and composition of the CD4 + T-cell population is regulated by balanced proliferation of progenitor cells and death of mature progeny. After infection with the human immunodeficiency virus, this homeostasis is often disturbed and CD4 + T cells are instead depleted. Such depletion cannot result simply from accelerated destruction of mature CD4 + T cells — sources of T-cell production must also fail. Ironically, this failure may be precipitated by physiological mechanisms designed to maintain homeostasis in the face of accelerated T-cell loss.
ISSN:0028-0836
1476-4687
DOI:10.1038/35073648