The effects of hormone replacement therapy on lipid peroxidation and antioxidant status

Objective: A number of studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT). The aim of our study was to examine the effects of HRT on lipid peroxidation and antioxidant status, which were likely to be involved in the path...

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Bibliographic Details
Published in:Maturitas 2001-04, Vol.38 (2), p.165-170
Main Authors: Özden, Serin, Dildar, Konukoğlu, Kadir, Yelke Hakan, Gülizar, Kuğu
Format: Article
Language:English
Subjects:
Biological and medical sciences
Case-Control Studies
Coronary Artery Disease - prevention & control
Female
Glutathione
Glutathione - blood
Glutathione peroxidase
Glutathione Peroxidase - blood
Hormone Replacement Therapy
Hormones. Endocrine system
Humans
Lipid Peroxidation
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:Objective: A number of studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT). The aim of our study was to examine the effects of HRT on lipid peroxidation and antioxidant status, which were likely to be involved in the pathophysiology of atherosclerosis. Methods: We measured erythrocyte and plasma thiobarbituric acid reactive substances (TBARS) levels as expression of lipid peroxidation-end product malondialdehyde, and also erythrocyte reduced glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity as indicators of the antioxidant status of the 35 postmenopausal women with HRT (mean age: 51.81±4.57 yr; body mass index (BMI): 26.56±3.78 kg/m 2) and 35 postmenopausal women without HRT (mean age: 47.50±3.64; BMI: 27.42±3.43 kg/m 2). Results: In the group with HRT, erythrocyte and plasma TBARS levels were significantly lower than in the group without HRT ( P
ISSN:0378-5122
1873-4111
DOI:10.1016/S0378-5122(00)00216-4