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The effects of hormone replacement therapy on lipid peroxidation and antioxidant status
Objective: A number of studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT). The aim of our study was to examine the effects of HRT on lipid peroxidation and antioxidant status, which were likely to be involved in the path...
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| Published in: | Maturitas 2001-04, Vol.38 (2), p.165-170 |
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| Main Authors: | , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c455t-754fb08972a09e1edcefc09480b4f23e181c61fee80283f86c8e753c18cb3c413 |
| container_end_page | 170 |
| container_issue | 2 |
| container_start_page | 165 |
| container_title | Maturitas |
| container_volume | 38 |
| creator | Özden, Serin Dildar, Konukoğlu Kadir, Yelke Hakan Gülizar, Kuğu |
| description | Objective: A number of studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT). The aim of our study was to examine the effects of HRT on lipid peroxidation and antioxidant status, which were likely to be involved in the pathophysiology of atherosclerosis.
Methods: We measured erythrocyte and plasma thiobarbituric acid reactive substances (TBARS) levels as expression of lipid peroxidation-end product malondialdehyde, and also erythrocyte reduced glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity as indicators of the antioxidant status of the 35 postmenopausal women with HRT (mean age: 51.81±4.57 yr; body mass index (BMI): 26.56±3.78 kg/m
2) and 35 postmenopausal women without HRT (mean age: 47.50±3.64; BMI: 27.42±3.43 kg/m
2).
Results: In the group with HRT, erythrocyte and plasma TBARS levels were significantly lower than in the group without HRT (
P |
| doi_str_mv | 10.1016/S0378-5122(00)00216-4 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77060254</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378512200002164</els_id><sourcerecordid>77060254</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-754fb08972a09e1edcefc09480b4f23e181c61fee80283f86c8e753c18cb3c413</originalsourceid><addsrcrecordid>eNqFkFtL7DAQgIMoul5-goeCIJ6H6kyTtNknEfEcBcEHFR9DNp2wObRNTboH_fe27qKPPgwzDN9c-Bg7RjhHwPLiEXilcolFcQbwG6DAMhdbbIaq4rlAxG02-0L22H5K_wBAAhe7bA-RQ1mAnLGXpyVl5BzZIWXBZcsQ29BRFqlvjKWWuiEblhRN_56FLmt87-uspxjefG0GP7ZMV48xllNnpNNghlU6ZDvONImONvmAPf-5ebq-ze8f_t5dX93nVkg55JUUbgFqXhUG5oRUW3IW5kLBQriCEyq0JToiBYXiTpVWUSW5RWUX3ArkB-x0vbeP4XVFadCtT5aaxnQUVklXFZRQSDGCcg3aGFKK5HQffWviu0bQk1H9aVRPujSA_jSqp7lfmwOrRUv199RG4QicbACTrGlcNJ316Yubi0rB9OflmqJRxn9PUSfrqbNU-zi613XwPzzyAW2ckp4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77060254</pqid></control><display><type>article</type><title>The effects of hormone replacement therapy on lipid peroxidation and antioxidant status</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Özden, Serin ; Dildar, Konukoğlu ; Kadir, Yelke Hakan ; Gülizar, Kuğu</creator><creatorcontrib>Özden, Serin ; Dildar, Konukoğlu ; Kadir, Yelke Hakan ; Gülizar, Kuğu</creatorcontrib><description>Objective: A number of studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT). The aim of our study was to examine the effects of HRT on lipid peroxidation and antioxidant status, which were likely to be involved in the pathophysiology of atherosclerosis.
Methods: We measured erythrocyte and plasma thiobarbituric acid reactive substances (TBARS) levels as expression of lipid peroxidation-end product malondialdehyde, and also erythrocyte reduced glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity as indicators of the antioxidant status of the 35 postmenopausal women with HRT (mean age: 51.81±4.57 yr; body mass index (BMI): 26.56±3.78 kg/m
2) and 35 postmenopausal women without HRT (mean age: 47.50±3.64; BMI: 27.42±3.43 kg/m
2).
Results: In the group with HRT, erythrocyte and plasma TBARS levels were significantly lower than in the group without HRT (
P<0.003 and
P<0.001, respectively). Erythrocyte GSH level and GSH-Px activity was found to be increased significantly in the group with HRT in comparison with the group without HRT (
P<0.001 and
P<0.001, respectively). There was not any correlation between the erythrocyte and plasma TBARS and erythrocyte GSH levels and GSH-Px activity with duration of HRT (mean 3.5±1.3 yr).
Conclusion: Our results show that HRT is beneficial in the protection against oxidative damage and can prevent atherosclerotic complications.</description><identifier>ISSN: 0378-5122</identifier><identifier>EISSN: 1873-4111</identifier><identifier>DOI: 10.1016/S0378-5122(00)00216-4</identifier><identifier>PMID: 11306205</identifier><identifier>CODEN: MATUDK</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Case-Control Studies ; Coronary Artery Disease - prevention & control ; Female ; Glutathione ; Glutathione - blood ; Glutathione peroxidase ; Glutathione Peroxidase - blood ; Hormone Replacement Therapy ; Hormones. Endocrine system ; Humans ; Lipid Peroxidation ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Thiobarbituric Acid Reactive Substances - metabolism</subject><ispartof>Maturitas, 2001-04, Vol.38 (2), p.165-170</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-754fb08972a09e1edcefc09480b4f23e181c61fee80283f86c8e753c18cb3c413</citedby><cites>FETCH-LOGICAL-c455t-754fb08972a09e1edcefc09480b4f23e181c61fee80283f86c8e753c18cb3c413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=947801$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11306205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Özden, Serin</creatorcontrib><creatorcontrib>Dildar, Konukoğlu</creatorcontrib><creatorcontrib>Kadir, Yelke Hakan</creatorcontrib><creatorcontrib>Gülizar, Kuğu</creatorcontrib><title>The effects of hormone replacement therapy on lipid peroxidation and antioxidant status</title><title>Maturitas</title><addtitle>Maturitas</addtitle><description>Objective: A number of studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT). The aim of our study was to examine the effects of HRT on lipid peroxidation and antioxidant status, which were likely to be involved in the pathophysiology of atherosclerosis.
Methods: We measured erythrocyte and plasma thiobarbituric acid reactive substances (TBARS) levels as expression of lipid peroxidation-end product malondialdehyde, and also erythrocyte reduced glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity as indicators of the antioxidant status of the 35 postmenopausal women with HRT (mean age: 51.81±4.57 yr; body mass index (BMI): 26.56±3.78 kg/m
2) and 35 postmenopausal women without HRT (mean age: 47.50±3.64; BMI: 27.42±3.43 kg/m
2).
Results: In the group with HRT, erythrocyte and plasma TBARS levels were significantly lower than in the group without HRT (
P<0.003 and
P<0.001, respectively). Erythrocyte GSH level and GSH-Px activity was found to be increased significantly in the group with HRT in comparison with the group without HRT (
P<0.001 and
P<0.001, respectively). There was not any correlation between the erythrocyte and plasma TBARS and erythrocyte GSH levels and GSH-Px activity with duration of HRT (mean 3.5±1.3 yr).
Conclusion: Our results show that HRT is beneficial in the protection against oxidative damage and can prevent atherosclerotic complications.</description><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Coronary Artery Disease - prevention & control</subject><subject>Female</subject><subject>Glutathione</subject><subject>Glutathione - blood</subject><subject>Glutathione peroxidase</subject><subject>Glutathione Peroxidase - blood</subject><subject>Hormone Replacement Therapy</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Lipid Peroxidation</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><issn>0378-5122</issn><issn>1873-4111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkFtL7DAQgIMoul5-goeCIJ6H6kyTtNknEfEcBcEHFR9DNp2wObRNTboH_fe27qKPPgwzDN9c-Bg7RjhHwPLiEXilcolFcQbwG6DAMhdbbIaq4rlAxG02-0L22H5K_wBAAhe7bA-RQ1mAnLGXpyVl5BzZIWXBZcsQ29BRFqlvjKWWuiEblhRN_56FLmt87-uspxjefG0GP7ZMV48xllNnpNNghlU6ZDvONImONvmAPf-5ebq-ze8f_t5dX93nVkg55JUUbgFqXhUG5oRUW3IW5kLBQriCEyq0JToiBYXiTpVWUSW5RWUX3ArkB-x0vbeP4XVFadCtT5aaxnQUVklXFZRQSDGCcg3aGFKK5HQffWviu0bQk1H9aVRPujSA_jSqp7lfmwOrRUv199RG4QicbACTrGlcNJ316Yubi0rB9OflmqJRxn9PUSfrqbNU-zi613XwPzzyAW2ckp4</recordid><startdate>20010420</startdate><enddate>20010420</enddate><creator>Özden, Serin</creator><creator>Dildar, Konukoğlu</creator><creator>Kadir, Yelke Hakan</creator><creator>Gülizar, Kuğu</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010420</creationdate><title>The effects of hormone replacement therapy on lipid peroxidation and antioxidant status</title><author>Özden, Serin ; Dildar, Konukoğlu ; Kadir, Yelke Hakan ; Gülizar, Kuğu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-754fb08972a09e1edcefc09480b4f23e181c61fee80283f86c8e753c18cb3c413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Coronary Artery Disease - prevention & control</topic><topic>Female</topic><topic>Glutathione</topic><topic>Glutathione - blood</topic><topic>Glutathione peroxidase</topic><topic>Glutathione Peroxidase - blood</topic><topic>Hormone Replacement Therapy</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Lipid Peroxidation</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Özden, Serin</creatorcontrib><creatorcontrib>Dildar, Konukoğlu</creatorcontrib><creatorcontrib>Kadir, Yelke Hakan</creatorcontrib><creatorcontrib>Gülizar, Kuğu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Maturitas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Özden, Serin</au><au>Dildar, Konukoğlu</au><au>Kadir, Yelke Hakan</au><au>Gülizar, Kuğu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of hormone replacement therapy on lipid peroxidation and antioxidant status</atitle><jtitle>Maturitas</jtitle><addtitle>Maturitas</addtitle><date>2001-04-20</date><risdate>2001</risdate><volume>38</volume><issue>2</issue><spage>165</spage><epage>170</epage><pages>165-170</pages><issn>0378-5122</issn><eissn>1873-4111</eissn><coden>MATUDK</coden><abstract>Objective: A number of studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT). The aim of our study was to examine the effects of HRT on lipid peroxidation and antioxidant status, which were likely to be involved in the pathophysiology of atherosclerosis.
Methods: We measured erythrocyte and plasma thiobarbituric acid reactive substances (TBARS) levels as expression of lipid peroxidation-end product malondialdehyde, and also erythrocyte reduced glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity as indicators of the antioxidant status of the 35 postmenopausal women with HRT (mean age: 51.81±4.57 yr; body mass index (BMI): 26.56±3.78 kg/m
2) and 35 postmenopausal women without HRT (mean age: 47.50±3.64; BMI: 27.42±3.43 kg/m
2).
Results: In the group with HRT, erythrocyte and plasma TBARS levels were significantly lower than in the group without HRT (
P<0.003 and
P<0.001, respectively). Erythrocyte GSH level and GSH-Px activity was found to be increased significantly in the group with HRT in comparison with the group without HRT (
P<0.001 and
P<0.001, respectively). There was not any correlation between the erythrocyte and plasma TBARS and erythrocyte GSH levels and GSH-Px activity with duration of HRT (mean 3.5±1.3 yr).
Conclusion: Our results show that HRT is beneficial in the protection against oxidative damage and can prevent atherosclerotic complications.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11306205</pmid><doi>10.1016/S0378-5122(00)00216-4</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0378-5122 |
| ispartof | Maturitas, 2001-04, Vol.38 (2), p.165-170 |
| issn | 0378-5122 1873-4111 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Biological and medical sciences Case-Control Studies Coronary Artery Disease - prevention & control Female Glutathione Glutathione - blood Glutathione peroxidase Glutathione Peroxidase - blood Hormone Replacement Therapy Hormones. Endocrine system Humans Lipid Peroxidation Medical sciences Middle Aged Pharmacology. Drug treatments Thiobarbituric Acid Reactive Substances - metabolism |
| title | The effects of hormone replacement therapy on lipid peroxidation and antioxidant status |
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