Coagulation assessment in healthy pigs undergoing single xenon anaesthesia and combinations with isoflurane and sevoflurane

Background: With the introduction of new anaesthetics into clinical practice possible side effects of these novel anaesthetics have to be evaluated. This study was performed to clarify whether xenon or combinations of xenon with isoflurane or sevoflurane modify blood coagulation. Methods: The study...

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Published in:Acta anaesthesiologica Scandinavica 2001-05, Vol.45 (5), p.634-638
Main Authors: Horn, N. A., Hecker, K. E., Bongers, B., Baumert, H. J., Reyle-Hahn, S. M., Rossaint, R.
Format: Article
Language:English
Subjects:
Anesthesia, Inhalation
Anesthetics, Inhalation
Anesthetics. Neuromuscular blocking agents
Animals
Biological and medical sciences
blood coagulation
Blood Coagulation - drug effects
Blood Pressure - drug effects
Female
Inhalation anesthetics
Isoflurane
Medical sciences
Methyl Ethers
Neuropharmacology
Pharmacology. Drug treatments
Platelet Function Tests
Sevoflurane
Swine
Thrombelastography
Xenon
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Summary:Background: With the introduction of new anaesthetics into clinical practice possible side effects of these novel anaesthetics have to be evaluated. This study was performed to clarify whether xenon or combinations of xenon with isoflurane or sevoflurane modify blood coagulation. Methods: The study was performed in 20 healthy pigs which first underwent xenon anaesthesia (65 Vol%) and were then randomly assigned to combinations of xenon and isoflurane or sevoflurane at varying concentrations. During anaesthesia the following parameters were controlled: aPTT, PT, fibrinogen concentrations and thrombelastographic measurements. Results: Xenon monoanaesthesia did not alter significantly any coagulation parameter. When isoflurane was introduced the aPTT showed a significant increase while fibrinogen concentration decreased. The introduction of sevoflurane led also to a decrease in fibrinogen concentration, while the aPTT was unchanged. These decreases in fibrinogen concentration were not accompanied by reduced maximal clot strength or elevated fibrinolysis evaluated by thrombelastography. Although the above‐described changes were statistically significant, none of the parameters throughout the experiment exceeded the limits of normal values. Conclusion: In our study, xenon monoanaesthesia and combinations of xenon with isoflurane and sevoflurane did not lead to pathologic alterations in the measured coagulation parameters.
ISSN:0001-5172
1399-6576
DOI:10.1034/j.1399-6576.2001.045005634.x