Different Deficiencies in the Prevention of Tumorigenic-Low-Metastatic Murine K-1735b Melanoma Cells From Producing Metastases

To produce metastasis, malignant tumor cells must be able to complete a sequence of many steps that depend not only on tumor cell properties but also on ability of the tumor cells to interact effectively with host homeostatic mechanisms to avoid destruction. Therefore, it should be possible to isola...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1986-10, Vol.77 (4), p.915-924
Main Authors: Aukerman, Sharon Lea, Price, Janet E., Fidler, Isaiah J.
Format: Article
Language:English
Subjects:
Animals
Antigens, Neoplasm - immunology
Biological and medical sciences
Cell Division
Cell Line
Clone Cells - pathology
Dissemination
Liver - pathology
Lung - pathology
Male
Medical sciences
Melanoma - immunology
Melanoma - pathology
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Microscopy, Electron, Scanning
Neoplasm Metastasis - pathology
Neoplasms, Experimental - etiology
Tumor cell
Tumors
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Summary:To produce metastasis, malignant tumor cells must be able to complete a sequence of many steps that depend not only on tumor cell properties but also on ability of the tumor cells to interact effectively with host homeostatic mechanisms to avoid destruction. Therefore, it should be possible to isolate clonal populations of cells from a heterogeneous tumor that contain different singular or multiple deficiencies that render these clonal populations non- or low metastatic. In a study of K-1735 clones introduced into normal syngeneic hosts, the reasons for the lack of or low ability of metastasis production did indeed differ among different clones. Some clones were identified that were low metastatic in syngeneic C3H/HeN mice because of antigenic characteristics. Others failed to give rise to metastases because they could not survive and grow once arrested in the lung parenchyma. These data suggested that the success of future studies dealing with genetic analyses of the metastatic phenotype could depend on the use of appropriate tumor cell populations.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/77.4.915