Functional effects of unilateral laser papillectomy in the pig

Objectives. To evaluate the use of endoscopic laser papillectomy in a multi-papillary animal model to unilaterally impair concentrating ability and increase the urinary flow rate. Methods. Domestic pigs underwent unilateral retrograde flexible nephroscopy. With a holmium:yttrium-aluminum-garnet lase...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2001-04, Vol.57 (4), p.832-836
Main Authors: Seifman, Brian D, Rubin, Mark A, Williams, Antoinette L, Wolf, J.Stuart
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Creatine - metabolism
Female
Kidney - pathology
Kidney - physiopathology
Kidney Calculi - prevention & control
Kidney Function Tests
Kidney Medulla - surgery
Laser Therapy
Medical sciences
Organ Size
Pilot Projects
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Swine
Ureteroscopy - methods
Urodynamics
Water - metabolism
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Summary:Objectives. To evaluate the use of endoscopic laser papillectomy in a multi-papillary animal model to unilaterally impair concentrating ability and increase the urinary flow rate. Methods. Domestic pigs underwent unilateral retrograde flexible nephroscopy. With a holmium:yttrium-aluminum-garnet laser, varying numbers of papillae were ablated. Four weeks after the procedure, renal function studies were performed during hydropenia and after hydration, the animals were killed, and the kidneys were examined histologically. Results. The urine flow rate per 100 mL creatinine clearance was significantly increased in the papillectomized kidney compared with the control kidney during hydropenia (1.50 versus 0.94, P
ISSN:0090-4295
1527-9995
DOI:10.1016/S0090-4295(00)01121-3