Coffee consumption and serum lipids: A meta-analysis of randomized controlled clinical trials

Coffee drinking has been associated with increased serum cholesterol levels in some, but not all, studies. A Medline search of the English-language literature published prior to December 1998, a bibliography review, and consultations with experts were performed to identify 14 published trials of cof...

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Bibliographic Details
Published in:American journal of epidemiology 2001-02, Vol.153 (4), p.353-362
Main Authors: SUN HA JEE, JIANG HE, APPEL, Lawrence J, WHELTON, Paul K, SUH, I. I, KLAG, Michael J
Format: Article
Language:English
Subjects:
Adult
Air. Soil. Water. Waste. Feeding
Biological and medical sciences
Cholesterol - blood
Cholesterol, LDL - blood
Cholesterol, LDL - drug effects
Coffee - adverse effects
Environment. Living conditions
Female
Food Handling - methods
Human physiology applied to population studies and life conditions. Human ecophysiology
Humans
Male
Medical sciences
Middle Aged
Nutritional survey. Food supply and nutritional requirement
Public health. Hygiene
Public health. Hygiene-occupational medicine
Randomized Controlled Trials as Topic
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Summary:Coffee drinking has been associated with increased serum cholesterol levels in some, but not all, studies. A Medline search of the English-language literature published prior to December 1998, a bibliography review, and consultations with experts were performed to identify 14 published trials of coffee consumption. Information was abstracted independently by two reviewers using a standardized protocol. With a random-effects model, treatment effects were estimated by pooling results from individual trials after weighting the results by the inverse of total variance. A dose-response relation between coffee consumption and both total cholesterol and LDL cholesterol was identified (p < 0.01). Increases in serum lipids were greater in studies of patients with hyperlipidemia and in trials of caffeinated or boiled coffee. Trials using filtered coffee demonstrated very little increase in serum cholesterol. Consumption of unfiltered, but not filtered, coffee increases serum levels of total and LDL cholesterol.
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/153.4.353