Interleukin‐6 promoter polymorphism (−174 G/C) in Caucasian German patients with systemic lupus erythematosus

Background. A biallelic polymorphism (−174 G/C) within the interleukin‐6 (IL‐6) promoter reportedly has functional importance through the modulation of IL‐6 expression in vitro and in vivo. Methods. We performed a population‐based case–control study to analyse the association of the −174 G/C polymor...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2001-04, Vol.40 (4), p.393-400
Main Authors: Schotte, H., Schlüter, B., Rust, S., Assmann, G., Domschke, W., Gaubitz, M.
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies, Antinuclear - biosynthesis
Anti‐histone antibodies
Biological and medical sciences
Case–control studies
Caucasian German patients
Cytokines
Discoid skin lesions
Disease susceptibility
DNA - immunology
European Continental Ancestry Group
Female
Genetics
Germany
Humans
Interleukin-6 - genetics
Interleukin‐6
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - immunology
Male
Medical sciences
Middle Aged
Polymorphism, Genetic
Promoter polymorphism
Promoter Regions, Genetic
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Systemic lupus erythematosus
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Summary:Background. A biallelic polymorphism (−174 G/C) within the interleukin‐6 (IL‐6) promoter reportedly has functional importance through the modulation of IL‐6 expression in vitro and in vivo. Methods. We performed a population‐based case–control study to analyse the association of the −174 G/C polymorphism with disease susceptibility and clinical manifestations in 211 German patients with systemic lupus erythematosus (SLE). Results. There were no significant differences in allelic and genotypic frequencies between patients and healthy controls. Comparing patients with various disease manifestations, we found an association of the −174 G allele with discoid skin lesions (Pc=0.034) and anti‐histone antibodies (Pc=0.009). Conclusions. The IL‐6 promoter polymorphism −174 G/C does not contribute significantly to disease susceptibility, but predisposes to distinct clinical and immunological features. A genetically determined high IL‐6 response may have a pathogenic role under these conditions.
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/40.4.393