Genetic and serotypic characterization of Sin Nombre-like viruses in Canadian Peromyscus maniculatus mice

In Canada, hantavirus infected deer mice ( Peromyscus maniculatus) have been collected from British Columbia to Newfoundland. Partial sequencing of G1 and N protein encoding regions from Canadian Peromyscus maniculatus-borne hantaviruses demonstrated the existence of significant genotypic divergence...

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Bibliographic Details
Published in:Virus research 2001-05, Vol.75 (1), p.75-86
Main Authors: Drebot, Michael A., Gavrilovskaya, Irina, Mackow, Erich R., Chen, Zhaoxia, Lindsay, Robbin, Sanchez, Angela J., Nichol, Stuart T., Artsob, Harvey
Format: Article
Language:English
Subjects:
AG1 protein
Amino Acid Sequence
AN protein
Animals
Canada
Capsid - genetics
Capsid Proteins
Deer mouse
Genotyping
Hantavirus
Hantavirus - classification
Hantavirus - genetics
Hantavirus - immunology
Molecular Sequence Data
Neutralization Tests
Peromyscus - virology
Phylogeny
Sequence Alignment
Serology
Sin Nombre virus
Viral Core Proteins - genetics
Viral Envelope Proteins - genetics
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Summary:In Canada, hantavirus infected deer mice ( Peromyscus maniculatus) have been collected from British Columbia to Newfoundland. Partial sequencing of G1 and N protein encoding regions from Canadian Peromyscus maniculatus-borne hantaviruses demonstrated the existence of significant genotypic divergence among strains. Phylogenetic analysis showed that Sin Nombre (SN)-like viruses from eastern and western Canadian deer mice can be divided into at least two broad-based genogroups. Sequencing of mitochondrial DNA from infected deer mice originating from various eastern and western provinces showed that SN-like virus genogroups appeared to be associated with distinct haplotypes of mice. Sera from deer mice infected with eastern and western viral genotypes neutralized the Sin Nombre virus strain, Convict Creek 107, but not the New York 1 hantavirus. Despite the genetic heterogeneity of Canadian SN-like strains these hantaviruses do not appear to define unique hantavirus serotypes.
ISSN:0168-1702
1872-7492
DOI:10.1016/S0168-1702(01)00227-1