Involvement of disregulated c-myc but not c-sis/PDGF in atypical and anaplastic meningiomas

We investigated the expression of c-myc and c-sis/PDGF mRNA and protein products in 20 cases of meningiomas of various grades: 10 benign, 5 atypical and 5 anaplastic meningiomas. All cases of atypical and anaplastic meningiomas were positive for c-myc protein and mRNA by immunohistochemistry and in...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2001-04, Vol.103 (1), p.13-18
Main Authors: Nagashima, Goro, Aoyagi, Masaru, Yamamoto, Shinji, Wakimoto, Hiroaki, Tamaki, Masashi, Yamamoto, Kiyotaka, Fujimoto, Tsukasa, Hirakawa, Kimiyoshi
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
c-myc
c-sis/PDGF
Female
Gene Expression Regulation, Neoplastic
Humans
IHC
Immunohistochemistry
In Situ Hybridization
ISH
Male
Malignant
Medical sciences
Meningeal Neoplasms - chemistry
Meningeal Neoplasms - classification
Meningeal Neoplasms - genetics
Meningeal Neoplasms - pathology
Meningioma
Meningioma - chemistry
Meningioma - classification
Meningioma - genetics
Meningioma - pathology
Middle Aged
Neoplasm Proteins - analysis
Neoplasm Proteins - genetics
Neurology
Phosphoproteins - analysis
Phosphoproteins - genetics
Proto-Oncogene Proteins c-myc - analysis
Proto-Oncogene Proteins c-myc - genetics
Proto-Oncogene Proteins c-sis - analysis
Proto-Oncogene Proteins c-sis - genetics
RNA, Messenger - analysis
Tumors of the nervous system. Phacomatoses
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Summary:We investigated the expression of c-myc and c-sis/PDGF mRNA and protein products in 20 cases of meningiomas of various grades: 10 benign, 5 atypical and 5 anaplastic meningiomas. All cases of atypical and anaplastic meningiomas were positive for c-myc protein and mRNA by immunohistochemistry and in situ hybridisation, respectively, while all 10 benign meningiomas were negative for c-myc immunostaining, with only one benign tumour positive for c-myc mRNA. Expression of PDGF-BB protein and c-sis mRNA were seen in more than 80% of the meningioma cases and was not restricted to the histological grades of meningiomas. Semiquantitive analysis showed that the frequency of c-myc immunopositive cells positively correlated with Ki-67 proliferative indices. Our findings suggest that c-myc, but not c-sis/PDGF, has some concern to the malignancy of meningiomas.
ISSN:0303-8467
1872-6968
DOI:10.1016/S0303-8467(00)00119-0