Biogenic amines in the human neocortex in patients with neocortical and mesial temporal lobe epilepsy: identification with in situ microvoltammetry

Biogenic amines in well defined subtypes of human temporal lobe epilepsy (TLE) have not been well characterized. Specimens from five patients with neocortical TLE (NTLE) and nine with mesial TLE (MTLE) were immediately placed in Ringer’s lactate; stearate indicator microelectrodes were placed in tem...

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Bibliographic Details
Published in:Brain research 2001-04, Vol.899 (1), p.106-111
Main Authors: Pacia, Steven V, Doyle, Werner K, Broderick, Patricia A
Format: Article
Language:English
Subjects:
Biogenic Amines - metabolism
Biological and medical sciences
Chi-Square Distribution
Dopamine
Electrochemistry - instrumentation
Electrochemistry - statistics & numerical data
Epilepsy
Epilepsy, Temporal Lobe - metabolism
Epilepsy, Temporal Lobe - pathology
Epilepsy, Temporal Lobe - surgery
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Medical sciences
Microelectrodes
Microvoltammetry
Neocortex - metabolism
Neocortex - pathology
Neocortex - surgery
Nervous system (semeiology, syndromes)
Neurology
Neurotransmitter
Norepinephrine and ascorbic acid
Serotonin
Statistics, Nonparametric
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Summary:Biogenic amines in well defined subtypes of human temporal lobe epilepsy (TLE) have not been well characterized. Specimens from five patients with neocortical TLE (NTLE) and nine with mesial TLE (MTLE) were immediately placed in Ringer’s lactate; stearate indicator microelectrodes were placed in temporal gray matter, Ag/AgCl reference microelectrodes and auxiliary microelectrodes were placed 3–7 mm contralaterally to the indicator microelectrode. Dopamine (DA), ascorbic acid (AA), norepinephrine (NE) and serotonin (5-HT) were identified by their characteristic oxidative potentials in vitro. Four of five patients with NTLE had NE depletion in temporal neocortex while eight of nine patients with MTLE had high concentrations of NE (chi-square P
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(01)02214-4