Multidrug resistance gene expression during the murine ontogeny

Multidrug resistance (MDR) was described initially for tumor cells which become resistant not only to the specific drug to which they are submitted, but also to a large range of unrelated drugs. The expression of mdr genes, responsible for the phenotype, and their product P glycoprotein (Pgp), is cu...

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Bibliographic Details
Published in:Mechanisms of ageing and development 2001-03, Vol.122 (3), p.255-270
Main Authors: Schiengold, Marion, Schwantes, Lavı́nia, Schwartsmann, Gilberto, Chies, José Artur Bogo, Nardi, Nance Beyer
Format: Article
Language:English
Subjects:
Ageing
Animals
Animals, Newborn
ATP Binding Cassette Transporter, Subfamily B - genetics
ATP-Binding Cassette Transporters - genetics
Biological and medical sciences
Development. Metamorphosis. Moult. Ageing
Drug Resistance, Multiple - genetics
Embryonic and Fetal Development
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Profiling
Male
mdr
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Multidrug resistance
Murine ontogeny
Pgp
Protein Isoforms - genetics
Tissue Distribution
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Multidrug resistance (MDR) was described initially for tumor cells which become resistant not only to the specific drug to which they are submitted, but also to a large range of unrelated drugs. The expression of mdr genes, responsible for the phenotype, and their product P glycoprotein (Pgp), is currently under intensive study due to their ample distribution in different organisms and their possible physiological roles which include protection against xenobiotics. In mice, three mdr isoforms expressed in some normal tissues are known. In this work, we analyzed by RT-PCR the expression of mdr1, mdr2 and mdr3 in several organs of BALB/c and C57BL/6 mice during ontogeny. A considerable variation in mdr expression among individuals of the same strain, as well as among different organs in individuals of the same age group and among different age groups, was detected. We also observed a strong tendency for the expression of a greater number of active isoforms in old mice. The large expression range of the mdr isoforms point to an important role as a natural defense system.
ISSN:0047-6374
1872-6216
DOI:10.1016/S0047-6374(00)00223-2