Juxtaposition of CNR Protocadherins and Reelin Expression in the Developing Spinal Cord

The CNR (cadherin-related neuronal receptors) family of protocadherins is of great interest because of their potential roles as molecular tags in the formation of specific synaptic connections, and as receptors for reelin, during neuronal migration, and cell body positioning. In order to know more a...

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Bibliographic Details
Published in:Molecular and cellular neuroscience 2001-04, Vol.17 (4), p.611-623
Main Authors: Carroll, Patrick, Gayet, Odile, Feuillet, Christian, Kallenbach, Sacha, de Bovis, Béatrice, Dudley, Keith, Alonso, Serge
Format: Article
Language:English
Subjects:
Animals
Cadherins - genetics
Cell Adhesion Molecules, Neuronal - genetics
Dab1 protein
DNA, Complementary
Extracellular Matrix Proteins - genetics
Gene Expression Regulation, Developmental
In Situ Hybridization
Mice
Motor Neurons - chemistry
Motor Neurons - physiology
Nerve Tissue Proteins
Olfactory Pathways - cytology
Olfactory Pathways - embryology
Olfactory Pathways - physiology
Protein Precursors - genetics
Rats
reelin
Rhombencephalon - cytology
Rhombencephalon - embryology
Rhombencephalon - physiology
RNA, Messenger - analysis
Serine Endopeptidases
Signal Transduction - physiology
Spinal Cord - cytology
Spinal Cord - embryology
Spinal Cord - physiology
Visual Pathways - cytology
Visual Pathways - embryology
Visual Pathways - physiology
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Summary:The CNR (cadherin-related neuronal receptors) family of protocadherins is of great interest because of their potential roles as molecular tags in the formation of specific synaptic connections, and as receptors for reelin, during neuronal migration, and cell body positioning. In order to know more about potential functions of CNRs we have mapped their expression during mouse nervous system development and compared their expression with that of reelin and its intracellular effector Dab1 in several tissues. In spinal cord, CNRs and Dab1 are expressed in motoneurons, while reelin is located in adjacent cells. In the hindbrain, there is a differential expression of CNRs and Dab1 in various motor nuclei. In the retina and olfactory system, we observe CNR and reelin expression but not that of Dab1. These results provide new insights into the potential functions of CNRs and their possible integration in the reelin pathway during development.
ISSN:1044-7431
1095-9327
DOI:10.1006/mcne.2001.0966