Comparative Clinical Efficacy of Two Different Single-dose Ciprofloxacin Treatments for Uncomplicated Gonorrhea

• Published in: Sexually transmitted diseases 1986-07, Vol.13 (3), p.169-171
• Main Authors: AZNAR, JAVIER, PRADOS, RAFAEL, RODRIGUEZ-PICHARDO, ANTONIO, HERNANDEZ, ILDEFONSO, DE MIGUEL, CONSTANTINO, PEREA, EVELIO J.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Ciprofloxacin - administration & dosage; Ciprofloxacin - therapeutic use; Double-Blind Method; Gonorrhea - drug therapy; Humans; Male; Medical sciences; Pharmacology. Drug treatments; Random Allocation; Urethritis - drug therapy
• ISSN: 0148-5717; 1537-4521
• DOI: 10.1097/00007435-198607000-00012

The clinical efficacies of two different single-dose, oral treatments with ciprofloxacin were evaluated in a double-blind randomized study of 50 men with gonococcal urethritis. Two groups of patients were studied. The 25 patients in group A (age, 18-32 years; X̅ = 26.2) received a single dose of 250 mg of ciprofloxacin; the 25 in group (age, 16-42 years; X̅ = 263) received a single dose of 100 mg of ciprofloxacin. The minimal inhibitory concentrations of ciprofloxacin for all the isolates were ≤0.0015 μg/ml. Neisseria gonorrhoeae was eradicated from all 50 patients; 80% of them were clinically cured, and 20% developed postgonococcal urethritis. There was no significant difference between the two treatments evaluated. We conclude that a single oral dose of 100 mg of ciprofloxacin could be an alternative treatment for uncomplicated gonorrhea in men. Neither treatment prevented the development of postgonococcal urethritis.