Evidence for a migratory capability of rat Kupffer cells to portal tracts and hepatic lymph nodes

The present study concerns the migratory ability of Kupffer cells in the rat. Phagocytic cells were labeled with colloidal carbon or gold, these markers being administered intravenously either into a tail vein, which resulted in generalized reticuloendothelial uptake, or in low dose into the portal...

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Bibliographic Details
Published in:Virchows Archiv. Abteilung B. Zellpathologie 1986-12, Vol.51 (5), p.429-442
Main Authors: HARDONK, M. J, DIJKHUIS, F. W. J, GROND, J, KOUDSTAAL, J, POPPEMA, S
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell physiology
Fundamental and applied biological sciences. Psychology
Kupffer Cells - cytology
Kupffer Cells - physiology
Kupffer Cells - ultrastructure
Liver - cytology
Liver - physiology
Liver - ultrastructure
Lymph Nodes - physiology
Macrophages - physiology
Male
Microscopy, Electron
Molecular and cellular biology
Motility and taxis
Phagocytosis
Rats
Rats, Inbred Strains
Splenectomy
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Summary:The present study concerns the migratory ability of Kupffer cells in the rat. Phagocytic cells were labeled with colloidal carbon or gold, these markers being administered intravenously either into a tail vein, which resulted in generalized reticuloendothelial uptake, or in low dose into the portal vein, which produced uptake by Kupffer cells alone. Cells containing marker were observed in the portal tracts and in hepatic lymph nodes from 1 to 3 days after injection into the portal vein. The direct movement of single marker particles to the portal tracts could be excluded. Since injection of marker into the portal vein labeled Kupffer cells exclusively, whereas blood cells, splenic and bone marrow macrophages remained unlabeled, the labeled cells in the portal tracts and hepatic lymph nodes appeared to be former Kupffer cells migrating which had migrated to these sites.
ISSN:0340-6075
0042-6431
DOI:10.1007/bf02899050