Serum free light-chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma

Using sensitive, automated immunoassays, increased concentrations of either κ or λ free light chains (and abnormal κ/λ ratios) were detected in the sera of 19 of 28 patients with nonsecretory multiple myeloma. Four other patients had suppression of one or both light chains, and the remaining 5 sera...

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Bibliographic Details
Published in:Blood 2001-05, Vol.97 (9), p.2900-2902
Main Authors: Drayson, Mark, Tang, Lian X., Drew, Roger, Mead, Graham P., Carr-Smith, Hugh, Bradwell, Arthur R.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Culture Media, Serum-Free
Humans
Immunoassay
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulin kappa-Chains - blood
Immunoglobulin kappa-Chains - immunology
Immunoglobulin lambda-Chains - blood
Immunoglobulinopathies
Immunopathology
Medical sciences
Monitoring, Physiologic
Multiple Myeloma - blood
Multiple Myeloma - immunology
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Summary:Using sensitive, automated immunoassays, increased concentrations of either κ or λ free light chains (and abnormal κ/λ ratios) were detected in the sera of 19 of 28 patients with nonsecretory multiple myeloma. Four other patients had suppression of one or both light chains, and the remaining 5 sera had normal or raised free light-chain concentrations with substantially normal κ/λ ratios. Six of the patients with an elevated single free light chain, who were studied during follow-up, had changes in disease activity that were reflected by the changes in free light-chain concentrations. It is concluded that quantification of free light chains in serum should prove useful for the diagnosis and monitoring of many patients with nonsecretory myeloma.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V97.9.2900